Adrenomedullin (AM) is a potent depressor peptide whose vascular action is suggested to involve nitric oxide (NO) release. To explore the role of endogenous AM in vascular and renal function, we examined the effects of acetylcholine (ACh), AM, and AM receptor antagonists AM(22-52) and CGRP(8-37) on the renal perfusion pressure (RPP) of kidneys isolated from AM transgenic (TG)/heterozygote knock...

The mechanisms for the vascular actions of vasodilatory beta-blockers remain undetermined. For some kinds of beta-blockers, the involvement of nitric oxide (NO) has been suggested. We studied the effects of vasodilatory beta-blockers on renal perfusion pressure (RPP) and NO release in the rat kidney. Infusion of bopindolol, celiprolol, and nebivolol caused a dose-dependent reduction in RPP and ...

This paper introduces a new method to deal with the Undirected Rural Postman Problem (RPP), based on Genetic Algorithms. The RPP is a particular Arc Routing Problem which consists of determining a minimum cost circuit on a graph so that it is possible to traverse a given subset of required edges. The RPP is known to be an NP-hard problem and it has some interesting real-life applications. The a...

RNase P catalyzes the Mg(2)(+)-dependent 5'-maturation of precursor tRNAs. Biochemical studies on the bacterial holoenzyme, composed of one catalytic RNase P RNA (RPR) and one RNase P protein (RPP), have helped understand the pleiotropic roles (including substrate/Mg(2+) binding) by which a protein could facilitate RNA catalysis. As a model for uncovering the functional coordination among multi...

I ecently several investigators have reported that neutrophil functions were depressed or defective in .̂localized and generalized juvenile periodontitis. It has also been shown that patients with adult periodontitis exhibit no such abnormalities. Concerning rapidly progressing periodontitis, only a few reports have been provided. The purpose of the present study was to compare various neutrophi...

Response of renal vasculature to changes in renal perfusion pressure (RPP) involves mechanisms with different frequency characteristics. Autoregulation of renal blood flow (RBF) is mediated by the rapid myogenic response, by the slower tubuloglomerular feedback (TGF) mechanism, and, possibly, by an even slower third mechanism. To evaluate the individual contribution of these mechanisms to RBF a...

The factors responsible for the development of hypertension during chronic activation of intrarenal V1receptors are unknown. We therefore tested whether medullary interstitial infusion of the selective V1-receptor agonist [Phe2,Ile3,Orn8]vasopressin (V1 agonist) influences renal antihypertensive mechanisms initiated by increased renal perfusion pressure (RPP). In intact anesthetized rabbits, th...

In this paper, we give an overview of power grid, smart grid, Advanced Metering Infrastructure (AMI), and the deployment cost analysis step by step. The importance between Relay Placement Problem (RPP) and the deployment cost in an AMI system is highlighted. Additionally, a decision supporting system in a pilot AMI system funded by National Science Council (NSC) is briefly described where RPP i...

INTRODUCTION The purpose of this study was to evaluate the oncological and functional outcome of retropubic and perineal approaches to radical prostatectomy. METHOD Data from 1,304 patients who underwent either radical retropubic (RRP) or radical perineal prostatectomy (RPP) over a 12-year period were compared. Variables included age, prostate-specific antigen (PSA) level preoperative, prosta...

The idea of left(right) palindromic permutations(LPPs,RPPs) and left(right) generalized Smarandache palindromic permutations(LGSPPs,RGSPPs) are introduced in symmetric groups Sn of degree n. It is shown that in Sn, there exist a LPP and a RPP and they are unique(this fact is demonstrated using S2 and S3). The dihedral group Dn is shown to be generated by a RGSPP and a LGSPP(this is observed to ...