INTRODUCTION We used immunoblots to determine whether inotropic and lusitropic effects of high-dose insulin (HDI) in cardiogenic shock, induced by a beta-blocker (BB) or a calcium channel blocker (CCB), are mediated by phosphorylation of phospholamban (PLB). PLB is a membrane protein that regulates calcium uptake into the sarcoplasmic reticulum (SR) by inhibition of the cardiac calcium pump (SE...

The incidence of diabetes is increasing globally. We investigated the relationship between diabetes prevalence and patient socioeconomic status across multiple countries. We searched PubMed to identify population-based surveys reporting diabetes prevalence between 1990 and May 2016. Search results were filtered, and Human Development Index (HDI) values from the United Nations Development Progra...

We propose the concept of human-data interaction (HDI) as the human manipulation, analysis, and sensemaking of large, unstructured, and complex datasets. We then proceed to suggest an embodied approach to HDI to build physical reasoning environments for these difficult and polymorphic tasks. We illustrate our approach with two examples: tangible lenses for visual exploration, and an educational...

PURPOSE The Janus-activated kinase/signal transducers and activators of transcription (STAT) pathway of IFN signaling is important to immunoregulation and tumor progression. STAT1 plays a prominent role in the effector immune response, whereas STAT3 is implicated in tumor progression and down-regulation of the response to type I IFNs. The goal of this study was to understand the effects of high...

BACKGROUND A healthy dietary pattern defined by international recommendations of the World Health Organisation (WHO) has been shown to reduce overall mortality risk. It is unknown whether this healthy dietary pattern is associated with overall cancer incidence. DESIGN In total 35,355 men and women within the Dutch European Prospective Investigation into Cancer and Nutrition-cohort were follow...

Background and Objectives: The main purpose of this study was to compare the predictive power of the Inequality-adjusted Human Development Index (IHDI) with the Human Development Index (HDI) with regard to the share of deaths caused by Non-Communicable Diseases (NCD) among all deaths in the world and Iran.   Methods: The data required for this cross-sectional ecological study were extracted f...

This study examined the effect of dependency ratio and unemployment rate on human development index in Aceh Province. used secondary data with type time series during 2002-2020 obtained from Central Bureau Statistics. The analysis method was Vector Auto Regression (VAR). results showed that HDI did not have a negative significant themselves, ABK had no HDI, TPT HDI.

Human Development Index (HDI) has been subject to a lot of criticism over time, with the idea that it does not fully reflect human development, and complemented different indicators in various studies. Despite its importance, especially considering requirements era, logistics considered HDI and, although there are many synthetic indices combine methods (i.e. DEA, MCDM etc.) HDI, these far from ...

Aim: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. Methods: Data from 21,837 participants aged ≥ 55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action Accepted: February 18, 2017 Published online: March 22, 2017 Agnes A.M. Berendsen Division of Human Nutrition Wageninge...

The Schisandraceae family is reported to have a range of pharmacological activities, including anti-inflammatory effects. As with all herbal preparations, extracts of Schisandra species are mixtures composed of >50 lignans, especially schizandrins, deoxyschizandrins, and gomisins. In China, Schisandra sphenanthera extract (SSE) is often coadministered with immunosuppressant treatment of transpl...