Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. The CS-boun...

Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA. To counteract the latter activity, bacteriophage λ encodes a small protein inhibitor called Gam that binds to RecBCD and inactivates the comple...

Pervasive Developmental Disorder (PDD) is a categorical term used to classify disorders in which the patient suffers deficits in three main domains: language, behavior and social skills. Heparin Binding Growth Associated Molecule (HB-GAM) is an extracellular protein involved in neurite outgrowth and radial migration. Mice deficient in HB-GAM demonstrate deficits in cognition, behavior and socia...

Quadrature amplitude modulation (QAM), deployed in billions of communication devises, exhibits a shaping-loss of πe/6 (≈ 1.53 dB) compared to the Shannon-Hartley theorem. With inspiration gained from special (leaf, flower petal, and seed) packing arrangements (so called spiral phyllotaxis) found among plants, we have designed a shape-versatile, circular symmetric, modulation scheme, the Golden ...

A generalized additive model (GAM) of blue shark, Prionace glauca, catch rates (catch per set) was ®tted to data gathered by National Marine Fisheries Service (NMFS) observers stationed aboard Hawaii-based commercial longline vessels (N ˆ 2010 longline sets) from March 1994 to December 1997. Its coef®cients were then applied to the values of predictor variables, which were also contained in log...

Generalized Additive Models (GAM) are a widely popular class of regression models to forecast electricity demand, due to their high accuracy, flexibility and interpretability. However, the residuals of the fitted GAM are typically heteroscedastic and leptokurtic caused by the nature of energy data. In this paper we propose a novel approach to estimate the time-varying conditional variance of th...

Gallium is a trivalent semi-metal with anti-microbial effects because of its incorporation into crucial iron-dependent reproductive enzyme systems. Gallium maltolate (GaM) provides significant gallium bioavailability to people and mice following oral administration and to neonatal foals following intragastric administration. To study the prophylactic and therapeutic effects of GaM against Rhodo...

Cartilage defects resulting from traumatic injury or degenerative diseases have very limited spontaneous healing ability. Recent progress in tissue engineering and local therapeutic gene delivery systems has led to promising new strategies for successful regeneration of hyaline cartilage. In the present study, tissue engineering and local therapeutic gene delivery systems are combined with the ...

Generalized approximation technique for a solution of one-dimensional steady state heat transfer problem in a slab made of a material with temperature dependent thermal conductivity, is developed. The results obtained by the generalized approximation method (GAM) are compared with those studied via homotopy perturbation method (HPM). For this problem, the results obtained by the GAM are more ac...