In metazoans, each cell type follows a characteristic, spatio-temporally regulated DNA replication program. Histone modifications (HMs) and chromatin binding proteins (CBPs) are fundamental for a faithful progression and completion of this process. However, no individual HM is strictly indispensable for origin function, suggesting that HMs may act combinatorially in analogy to the histone code ...

Many cities have been built along large rivers. The rivers can provide a source of drinking water, act as receiving water for treated effluent, provide navigation for shipping, and other beneficial uses. However, the city must also be protected from flooding due to the close proximity to the river. Hydrologic analysis plays a crucial role in the development of plans for protecting a river city....

Single-cell recording, electrolytic lesion and electrical stimulation studies have indicated that the pontomedullary reticular formation (PMRF) plays a role in head movement (HM) control. However, recent studies utilizing excitotoxin lesions of the PMRF have reported no effect on HM. In the present study, we have examined the acute and chronic motor effects of injecting ibotenic acid (IBO) into...

PURPOSE To assess the clinical features and distribution of brain metastases (BMs) of small cell lung cancer (SCLC) in the hippocampal and perihippocampal region, with the purpose of exploring the viability of hippocampal-sparing whole-brain radiation therapy (HS-WBRT) on reducing neurocognitive deficits. METHODS This was a retrospective analysis of the clinical characteristics and patterns o...

INTRODUCTION Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes. This study investigated the cellular and molecular changes as well as which inflammatory recepto...

Heteroplasmy, the mixture of mitochondrial genomes (mtDNA), varies among individuals and cells. Heteroplasmy levels alter the penetrance of pathological mtDNA mutations, and the susceptibility to age-related diseases such as Parkinson's disease. Although mitochondrial dysfunction occurs in age-related type 2 diabetes mellitus (T2DM), the involvement of heteroplasmy in diabetes is unclear. We hy...

conclusions pine trees can be used as a worthy bio-indicator for hms pollution monitoring in the ambient air in areas with extensive vegetation of pine trees. results iron had the highest concentration (345.0053 mg/kg) in leaves when compared with other hms. the concentration of zn, cu, pb and cd were 26.1384, 5.5905, 2.9963 and 0.7383 mg/kg, respectively. spatial mapping indicated that industr...

Worldwide competition among manufacturing enterprises has acted as a driving force for the design, development and utilization of manufacturing systems with an increased degree of agility. In these regards, Holonic Manufacturing Systems (HMS) are considered an intelligent systems paradigm to meet requirements for agile manufacturing systems. Despite all advantages of HMS, design and implementat...

Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square...