نتایج جستجو برای: مدلhec ras

تعداد نتایج: 29885  

Journal: :Molecular cancer research : MCR 2003
Roberta M James Mark J Arends Sarah J Plowman David G Brooks Colin G Miles John D West Charles E Patek

Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathways and thereby affect fundamental cellular processes, including proliferation, apoptosis, and differentiation. K-ras activating mutations play a key role in neoplastic progression and are particularly prevalent in colorectal, pancreatic, and lung cancers. The present study addressed whether the K...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Thomas Illmer Christian Thiede Anke Fredersdorf Sylvia Stadler Andreas Neubauer Gerhard Ehninger Markus Schaich

PURPOSE Activation of the RAS pathway plays a major role in cancer cells. In acute myeloid leukemia (AML), mutations of the RAS genes cause an intrinsic activation of this pathway. Until now, clinical studies could not find clear association of RAS mutations with the clinical outcome after AML therapy. This could be due to alternative initiating events for activation of the RAS pathway like con...

Journal: :Molecular and cellular biology 2003
Sarah J Plowman D James Williamson Maureen J O'Sullivan Jennifer Doig Ann-Marie Ritchie David J Harrison David W Melton Mark J Arends Martin L Hooper Charles E Patek

In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed during development, K-ras 4A expression is regulated temporally and spatially and occurs in adult kidney, intestine, stomach, and liver. In the pres...

Journal: :Cancer research 1998
T A Thompson K Kim M N Gould

Exclusive activation of either the Harvey-, Kirsten-, or N-ras gene is often found in human and rodent cancers, although the mechanisms responsible for tissue-specific ras gene activation are poorly understood. In this study, the contribution of ras gene expression and Ras protein activity to the tissue-specificity of ras gene activation was investigated using the rat mammary carcinogenesis mod...

Journal: :Cancer research 2003
Mi-Sung Kim Eun-Jung Lee Hyeong-Reh Choi Kim Aree Moon

Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer,including the degrees of invasion and tumor recurrence.We showed previously that H-ras, but not N-ras, up-regulates matrix metalloproteinase 2 expression and induces invasive phenotype in MCF10A human breast epithelial cells (A. Moon, et al. Int. J. Cancer, 85: 176-181, 2000). In this study, we show that H-r...

Journal: :Journal of virology 1998
J Guo K Williams S M Duboise L Alexander R Veazey J U Jung

STP-C488 (STP of herpesvirus saimiri [HVS] group C strain 488 [C488]) is the only virus-encoded protein found to associate with cellular ras and activate ras signal transduction pathways. To investigate an important role for ras signal transduction in STP-dependent growth transformation, we constructed recombinant strains of HVS C488 in which the STP-C488 oncogene was replaced with cellular nor...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده کشاورزی 1391

چکیده بررسی جریان غیرماندگار که جریان سیلاب نیز از آن جمله است دارای اهمیت بسیاری در مهندسی رودخانه می باشد. از آنجا که این نوع جریان پیچیدگی های خاص خود را دارد، بنابراین شبیه سازی جریان با مدل های ریاضی یکی از دقیق ترین و ارزان ترین روش هاست. در این تحقیق جریان غیرماندگار در بازه ای از رودخانه آجی چای به طول تقریبی 35 کیلومتر واقع در استان آذربایجان شرقی بررسی گردید. بدین منظور از دو مدل ریا...

Background  and aim : Recurrent aphthous stomatitis  is one of  the most common inflammatory diseases of the oral mucosa with multifactorial etiology  . Psychological factors  is  one of possible factors cause to recurrent aphthous ulcers and salivary cortisol level also influenced by anxiety, this study aimed  to compare salivary cortisol  levels in patients with recurrent aphthous ulcers( ...

Journal: :The Journal of biological chemistry 1994
E Porfiri T Evans P Chardin J F Hancock

We have studied whether hSOS1, a mammalian guanine nucleotide exchange factors responsible for activating Ras in response to growth factor stimulation, requires post-translational processing of Ras proteins to promote guanine nucleotide exchange. Our results showed that full-length hSOS1 catalyzed guanine nucleotide exchange on prenylated K-Ras(4B) but with a much lower efficiency on unprocesse...

Journal: :caspian journal of enviromental sciences 0

rivers are important water resources for human life, but sometimes cause irreparable damages. the flood plains are fertile terrains which are endangered by flood. flood hazard mapping is one of the basic methods in flood fighting. in order to decline flood damages, the simulation of the hydraulic behavior of the rivers during flood occurrence is very important. in this study, areas that are flo...

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