Patients with renal failure have a higher risk for cerebrovascular events and silent brain damage and a higher cardiovascular mortality rate when compared with the general population. We present two cases where alteplase was used for hemodialysis patients (HP) with acute ischemic stroke (AIS). A 70-year-old Caucasian female with a 2-year history of hemodialysis was admitted with right hemipares...

BACKGROUND AND PURPOSE Intravenous (IV) tissue plasminogen activator (tPA) is the only Food and Drug Administration (FDA)-approved treatment for acute ischemic stroke. Post tPA patients are typically monitored in an intensive care unit (ICU) for at least 24 hours. However, rigorous evidence to support this practice is lacking. This study evaluates factors that predict ICU needs after IV thrombo...

BACKGROUND Presence of medical complications in stroke patients has been established. The efficacy of a stroke score in intensive monitoring of these complications in acute ischaemic stroke patients has not been studied. METHODS Eighty-seven patients with acute ischaemic stroke were assessed with National Institute of Health Stroke Scale (NIHSS) by the examiner within days of admission; (1, 7...

BACKGROUND We aimed to validate three widely used scales in stroke research in a multiethnic Brazilian population. METHODS The National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and Barthel Index (BI) were translated, culturally adapted and applied by two independent investigators. The mRS was applied with or without a previously validated structured interview. In...

Introduction: Ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. The aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.Methods: In a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (CTEE) who admitted to Im...

BACKGROUND AND PURPOSE We derived and validated the Cincinnati Prehospital Stroke Severity Scale (CPSSS) to identify patients with severe strokes and large vessel occlusion (LVO). METHODS CPSSS was developed with regression tree analysis, objectivity, anticipated ease in administration by emergency medical services personnel and the presence of cortical signs. We derived and validated the too...

BACKGROUND AND PURPOSE The 15-item National Institutes of Health Stroke Scale (NIHSS) is a quantitative measure of stroke-related neurological deficit with established reliability and validity for use in clinical research. An abridged 11-item modified NIHSS (mNIHSS) has been described that simplifies or eliminates redundant and less reliable items. We aimed to determine whether the mNIHSS could...

Auditory stimulation increases mean blood flow velocity (MBFV) in the middle cerebral artery (MCA) in healthy individuals. Our aim was to monitor such changes in the affected MCA of patients with acute ischemic stroke (AIS). The study included 66 non-thrombolysed patients with AIS who were divided into groups according to National Institutes of Health Stroke Scale (NIHSS) score. Group I consist...

BACKGROUND Ischemic brain strokes consisttwo-thirdsof strokesand their complications bear a lot of disability for patient and society. In this study, we seek for effect of Erythropoietin on ischemic brain stroke's outcomes according to National Institutes of Health Stroke Scale (NIHSS) changes. METHODS This study is a RCT (randomized clinical trial). All patients with focal neurologic deficit...