Chemical treatment was used to modify the surface of microarc oxidized (MAO) coating containing Ca and P. And the chemically treated MAO (C-MAO) coating was further heat-treated at 400-800 degrees C. The average roughness of the MAO and C-MAO coatings is about 250 nm; further heat treatment improved the roughness of the C-MAO coating. The chemical and heat treatment enhanced the wetting ability...

BACKGROUND Studies of the biochemical properties of MAO-A (monoamine oxidase) are numerous, but the information about determination of MAO-A in human normal and tumour renal tissue is limited. Our objectives in the present study were to determine the localization of MAO-A in normal kidney and level of expression of this protein in tumour kidney. MATERIAL/METHODS Enzyme immunohistochemical met...

Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior. Chronic stressors and glucocorticoid-administration typically associate with elevated MAO-A levels/activity. However, the relationship of shorter stress or glucocorticoid exposures an...

The authors review the literature on the relationship of platelet monoamine oxidase (MAO) to affective disorders and alcoholism. Although some studies have reported an association between low platelet MAO and bipolar illness, others have failed to replicate this finding. Alcoholism has been related to affective disorders, and it is of note that three studies have found low MAO in alcoholics. Gi...

The quantitative structure-activity relationship (QSAR) analysis with comparative molecular field analysis (CoMFA) of indole derivatives-monoamine oxidase (MAO) inhibitors were done. The pharmacophore model included four features: two hydrophobic rings, one donor atom, and one acceptor site. The predictive values (cross-validated r2) of QSAR analysis for the inhibition of MAO-A and MAO-B were 0...

Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. MAO B is mainly localized in glial cells. MAO B also oxidizes the xenobiotic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to a parkinsonism-producing ne...

Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers. We examined the effects of phentermine and several other unlabeled MAO inhibitors on MAO activitie...

Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse. Of the intracellular METH target proteins, monoamine oxidase (MAO) is involved in the regulation of monoaminergic tone in the brain, resulting in the modulation of METH-induced behavioral abnormalities in mammals. The METH-induce...

The relation between precursors and restoration of A-form MAO activity in rat liver after administration of clorgyline to rats was investigated by measuring the rates of recovery of A-form MAO activity after treatment with the inhibitor. The half-lives of mitochondrial and microsomal A-form MAO were estimated as 3.5 and 2.0 days, respectively. MAO activity and the amount of MAO molecules were c...

Platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) activities were determined in 70 normal controls and 76 psychiatric patients. Platelet MAO activity did not differ between the normal controls and patients diagnosed as schizophrenic or primary affective illness, although there was a strong trend for chronic schizophrenics to have lower MAO activity. Schizophrenic patients with Sch...