Lineage potential is triggered by lineage-specific transcription factors in association with changes in the chromatin structure. Histone H3.3 variant is thought to play an important role in the regulation of lineage-specific genes. To elucidate the function of H3.3 in myogenic differentiation, we forced the expression of GFP-H3.1 to alter the balance between H3.1 and H3.3 in mouse C2C12 cells t...

Fatty acid binding protein 3 (Fabp3) has been used as a serological biomarker of cardiac injury, but its utility as a preclinical biomarker of injury to skeletal muscle is not well described. Fabp3 concentrations were determined for tissues from Sprague-Dawley rats and found to occur at highest concentrations in cardiac muscle and in skeletal muscles containing an abundance of type I fibers, su...

Randomized Kaczmarz, Motzkin Method and Sampling Kaczmarz (SKM) algorithms are commonly used iterative techniques for solving a system of linear inequalities (i.e., \(Ax \le b\)). As systems equations represent modeling paradigm many optimization problems, these randomized gaining popularity among researchers in different domains. In this work, we propose Generalized (GSKM) method that unifies ...

In vitro motility assays, where purified myosin and actin move relative to one another, are used to better understand the mechanochemistry of the actomyosin adenosine triphosphatase (ATPase) cycle. We examined the relationship between the relative velocity (V) of actin and myosin and the number of available myosin heads (N) or [ATP] for smooth (SMM), skeletal (SKM), and cardiac (CMM) muscle myo...

We examined the effect of early exercise training (Ex) on glucose kinetics, basal, and insulin-stimulated skeletal muscle (SKM) plasma membrane (PM) GLUT4 in pre- and/or postnatal nutrient-restricted adult rat offspring compared with sedentary (Sed) state. Pregestational control female (Ex CON vs. Sed CON) and offspring exposed to prenatal (Ex IUGR vs. Sed IUGR), postnatal (Ex PNGR vs. Sed PNGR...

Metabolic networks are characterized by complex interactions and regulatory mechanisms between many individual components. These interactions determine whether a steady state is stable to perturbations. Structural kinetic modeling (SKM) is a framework to analyze the stability of metabolic steady states that allows the study of the system Jacobian without requiring detailed knowledge about indiv...

Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed "myokines," has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR fami...

This study aims to evaluate the potential benefit of combination therapy of 2-methoxyestradiol (2ME) and magnetic nanoparticles of Fe(3)O(4) (MNPs-Fe(3)O(4)) on myelodysplastic syndrome (MDS) SKM-1 cells and its underlying mechanisms. The effect of the unique properties of tetraheptylammonium-capped MNPs-Fe(3)O(4) with 2ME on cytotoxicity was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt...

Penelitian ini digunakan untuk melihat kepuasan masyarakat terhadap pelayanan E-KTP di Dinas Kependudukan dan Pencatatan Sipil (Dispendukcapil) Kabupaten Sragen, yang dilaksanakan saat pandemi Covid-19 sehingga dapat sebagai acuan penilaian publik masa pandemi. Pelayanan dinilai menggunakan 5 variabel yaitu, bukti fisik (tangible), kehandalan (reliability), daya tanggap (responsiveness), jamina...

The sampling Kaczmarz–Motzkin (SKM) method is a generalization of the randomized Kaczmarz and Motzkin method. It first samples some rows coefficient matrix randomly to build set then makes use maximum violation criterion within this determine constraint. Finally, it progress by enforcing single In paper, based on SKM block strategies, we present two methods for consistent linear systems. Specif...