The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2MR) binds and internalizes several plasma proteins including tissue-type plasminogen activator (t-PA) and alpha 2-macroglobulin-protease complexes (alpha 2M*). A 39-kDa protein that copurifies with LRP/alpha 2MR inhibits the binding and uptake of ligands by LRP/alpha 2MR, including t-PA and alpha 2M*...

We show that the identity component Diff(M)0 of the group of Cr diffeomorphisms of a compact (2m)-dimensional manifold M2m (1 ≤ r ≤ ∞, r = 2m + 1) is uniformly perfect for 2m ≥ 6, i.e., any element of Diff(M)0 can be written as a product of a bounded number of commutators. It is also shown that for a compact connected manifold M2m (2m ≥ 6), the identity component Diff(M)0 of the group of Cr dif...

Recently, Z. Sun proved that 2 (2m + 1) ( 2m m ) | ( 6m 3m )( 3m m ) for m ∈ Z>0. In this paper, we consider a generalization of this result by defining bn,k = 2k (n + 2k − 2)!! (n− 2)!! k! . In this notation, Sun’s result may be expressed as 2 (2m + 1) | b(2m+1),(2m+1)−1 for m ∈ Z>0. In this paper, we prove that 2n | bn,un±2r for n ∈ Z>0 and u, r ∈ Z>0 with un ± 2r > 0. In addition, we prove a...

Best and Brouwer [Discrete Math. 17 (1977), 235– 245] proved that triply-shortened and doubly-shortened binary Hamming codes (which have length 2m − 4 and 2m − 3, respectively) are optimal. Properties of such codes are here studied, determining among other things parameters of certain subcodes. A utilization of these properties makes a computeraided classification of the optimal binary one-erro...

m-Qubit states are embedded in Cl2m Clifford algebra. Their probability spectrum then depends on O (2m)or O (2m+ 1)-invariants respectively. Parameter domains for O (2m (+1))-vector and -tensor configurations, generalizing the notion of a Bloch sphere, are derived.

Recent evidence suggests that T cells expressing gamma/delta antigen receptors (T cell receptor [TCR]) are subject to positive selection during development. We have shown that T cells expressing a class I major histocompatibility complex (MHC)-specific gamma/delta TCR transgene (tg) are not positively selected in class I MHC-deficient, beta 2-microglobulin (beta 2m) gene knockout mice (tg+ beta...

A systematic convolutional encoder of rate (n− 1)/n and maximum degree D generates a code of free distance at most D = D+ 2 and, at best, a column distance profile (CDP) of [2,3, . . . ,D ]. A code is Maximum Distance Separable (MDS) if it possesses this CDP. Applied on a communication channel over which packets are transmitted sequentially and which loses (erases) packets randomly, such a code...

Blood coagulation factor X plays a pivotal role in the clotting cascade. When administered intravenously to mice, the majority of activated factor X (factor Xa) binds to alpha 2-macroglobulin (alpha 2M) and is rapidly cleared from the circulation into liver. We show here that the low-density lipoprotein receptor-related protein (LRP) is responsible for factor Xa catabolism in vivo. Mice overexp...

It is well known that the degree of a 2m-variable bent function is at most m. However, the case in homogeneous bent functions is not clear. In this paper, it is proved that there is no homogeneous bent functions of degree m in 2m variables when m > 3; there is no homogenous bent function of degree m− 1 in 2m variables when m > 4; Generally, for any nonnegative integer k, there exists a positive...

For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2m(2)) who received capped doses (n=12) to those who received uncapped doses (n=24), and to patients with BSA≤2m(2) (n=42). The...