OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical ...

OBJECTIVES/HYPOTHESIS To investigate soluble syndecan-1 (Sdc-1) in the sera of patients with tongue squamous cell carcinoma (SCC) and its correlation with the histopathological criteria of tumors. STUDY DESIGN In a case-control study using a convenient method of sampling, 18 female and 25 male patients with confirmed diagnosis of tongue SCC, and 19 healthy females and 27 males were studied. ...

The sway-density curve (SDC) is computed by counting, for each time instant, the number of consecutive samples of the statokinesigram falling inside a circle of small radius R. The authors evaluated the sensitivity of the curve to the variation of R and found that in the range 3-5 mm the sensitivity was low, indicating that SDC is a robust descriptor of posturographic patterns. In addition, the...

Output Perturbation is one of several strategies in the area of Statistical Disclosure Control (SDC), also known as Private Data Analysis. The general problem in SDC consists of releasing valuable information about individuals in a databasewhile preserving their privacy. Examples of this include databases containing health information about patients, customer electronic transactions, and web br...

BACKGROUND After the publication of DIG trial, the therapeutic target of serum digoxin concentration (SDC) for the treatment of heart failure (HF) has been lowered (0.40-1.00 ng/ml). However, the majority of equations to calculate digoxin dosages were developed for higher SDCs. Recently, a new equation was validated in Asian population for low SDCs by Konishi et al., but results in Caucasians a...

The static (parallel-plate thermal-gradient) diffusion chamber (SDC) was one of the first instruments designed to measure cloud condensation nuclei (CCN) concentrations as a function of supersaturation. It has probably also been the most widely used type of CCN counter. This paper describes the detailed experimental characterization of 5 a SDC CCN counter, including calibration with respect to ...

BACKGROUND AND PURPOSE Salivary duct carcinoma (SDC) is regarded as a high-grade malignancy in the current classification of salivary gland neoplasms. The aim of our study was to describe the MR imaging features of SDC. METHODS Nine patients with SDC underwent MR imaging study. The apparent diffusion coefficient (ADC) values of SDCs were measured from diffusion-weighted images. Time-signal in...

BACKGROUND Salivary duct carcinoma (SDC) is a high-grade salivary gland malignancy that is associated with an aggressive clinical behavior and poor prognosis. Herein, we report on a long surviving case of SDC of the minor salivary gland with multiple lymph node metastases (LNMs). CASE PRESENTATION An 83-year-old woman presented with a history of lymphadenopathy in the right side of the neck a...

PURPOSE Salivary duct carcinomas (SDC) are a rare and aggressive subtype of salivary gland cancers for which cytotoxic chemotherapy has limited efficacy. We investigated whether genotyping analysis could detect novel tumor-specific mutations that would help direct SDC patient treatment using targeted agents. EXPERIMENTAL DESIGN We genotyped 27 SDC archival specimens from patients followed at ...

The aim of this study was to investigate the feasibility of using spray granulation as a drying method to convert phospholipid (PL)-sodium deoxycholate (SDC)-mixed micelles (MMs) containing a water-insoluble drug to a solid dosage form and to evaluate how drugs with significantly different physicochemical properties affect the spray granulation process and subsequent in vitro and in vivo proces...