Many software organizations have engaged in Software Process Improvement (SPI) and experienced the challenges related to managing such complex organizational change efforts. As a result, there is an increasing body of research investigating change management in SPI. To provide an overview of what we know and don’t know about SPI as organizational change, this paper addresses the following quest...

Nowadays, when software has become part of most everyday appliances, the significance of the software industry and especially small software companies is growing. The vast majority of companies world-wide are Small or Medium-sized Enterprises (SMEs). In Finland, over half of the software companies have only two to ten employees. Improving the operations of a company is necessary in order to mai...

PURPOSE To ascribe the serine protease inhibitor 3 (SPI-3) as an ocular acute inflammatory molecule and to clarify its producing cells in an endotoxin-induced uveitis (EIU) model. METHODS Male Wistar rats were injected with lipopolysaccharide (LPS), and the expression of SPI-3 mRNA in the ocular tissues was examined by in situ hybridization (ISH) and Northern blot analysis. A combination of I...

In order to survive inside macrophages, Salmonella produces a series of proteins encoded by genes within Salmonella pathogenicity island 2 (SPI-2). In the present study, we report that Fur, a central regulator of iron utilization, negatively controls the expression of SPI-2 genes. Time course analysis of SPI-2 expression after the entry of Salmonella into macrophages revealed that SPI-2 genes a...

Splenic B-2 cells can be divided into two major subsets: follicular (FO) and marginal zone (MZ) B cells. FO and MZ B cells are generated from immature transitional B cells. Few transcription factors have been identified that regulate FO B cell differentiation. The highly related proteins PU.1, Spi-B, and Spi-C are transcription factors of the E26-transformation-specific family and are important...

Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein-protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dysfunctions. Also, the Arabidopsis thaliana BDCP SPIRRIG (SPI) is important for ...

Field Programmable Gate Arrays (FPGA) are used widely in applications which require high speed parallel computing. It provides a perfect solution which requires short time for customization after manufacturing. MIPS soft-core processor and SPI protocol soft-core implementation is well known in FPGA, but the customized driver for SPI communication is not available. The SPI communication protocol...

We describe the molecular characterization of the Drosophila gene spitz (spi), which encodes a putative 26-kD, EGF-like transmembrane protein that is structurally similar to TGF-alpha. Temporal and spatial expression patterns of spi transcripts indicate that spi is expressed throughout the embryo. Examination of mutant embryos reveals that spi is involved in a number of unrelated developmental ...

We studied SPI in its organizational context through collaborative practice research (CPR), a particular form of action research. The CPR program involved close collaboration between practitioners and researchers over a three-year period to understand and improve SPI initiatives in four Danish software organizations. The problem of understanding and managing risks in SPI teams emerged in one of...