PURPOSE AND EXPERIMENTAL DESIGN Telomeres of tumor cells may be maintained by telomerase or by alternative lengthening of telomeres (ALT). The standard ALT assay requires Southern analysis of high molecular weight genomic DNA. We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in...

INTRODUCTION Information on treatment outcomes with interferon plus ribavirin combination therapy in chronic hepatitis C patients with normal alanine aminotransaminase (ALT) levels is limited. AIM The aims of this study were to assess outcomes of treatment with interferon plus ribavirin in patients with normal ALT levels (normal ALT group, n=52) compared with those with elevated ALT levels (r...

The availability of seven approved therapies, including five oral drugs, for chronic hepatitis B has expanded the indications for treatment. The decision to initiate treatment is easy in patients with liver failure, but there continues to be debate regarding when treatment should be initiated in patients with precirrhotic liver disease.1,2 Recognizing that liver biopsy is not performed on all p...

In this paper we do two things. In Section 2 we obtain complementary inequalities. That is, for 0 ≤ r ≤ 1 we obtain upper bounds on Tr[ABA] (in terms of the quantity Tr[ABA]), and lower bounds for r ≥ 1. Such bounds may be useful, for example, to obtain estimates on the error incurred by going from Tr[ABA] to Tr[ABA]. Second, in Section 3, we find a generalisation of the ALT inequality to gener...

Özet. Gömülü sistemler gün geçtikçe hayatımızın vazgeçilmez bir parçası haline gelmektedir. Bu sistemlerin performans ve kalite kriterleri diğer yazılım sistemlerinden farklı olduğundan, donanım ve yazılım alt parçalarının birlikte tasarlanmasını, geliştirilmesini ve sınanmasını gerektirir. Bu zorlukla artan karmaşıklığın daha iyi yönetilebilmesi için sıkça kullanılan bir yöntem, yüksek seviyed...