نتایج جستجو برای: ژن atm
تعداد نتایج: 29257 فیلتر نتایج به سال:
BACKGROUND Ataxia telangiectasia-mutated (ATM) gene downexpression has been reported in sporadic breast carcinomas (BC); however, the prognostic value and mechanisms of ATM deregulation remain unclear. PATIENTS AND METHODS ATM and miRNAs (miR-26a, miR-26b, miR-203, miR-421, miR-664, miR-576-5p and miR-18a) expression levels were evaluated by quantitative real-time PCR (RT-qPCR) in 52 BC and 3...
Location management is one of the most important aspects in the realization of mobility in wireless networks. Following developments of ATM (Asynchronous Transfer Mode) technology, more core networks become ATM-based. Therefore, the demand of mobility on wireless networks with ATM backbones is increasing. In recent years, several location management schemes have been proposed for classical wire...
Disruption of the mouse Atm gene, whose human counterpart is consistently mutated in ataxia-telangiectasia (A-T) patients, creates an A-T mouse model exhibiting most of the A-T-related systematic and cellular defects. While ATM plays a major role in signaling the p53 response to DNA strand break damage, Atm-/- p53(-/-) mice develop lymphomas earlier than Atm-/- or p53(-/-) mice, indicating that...
This paper deals with design and prototyping of mobility support protocols for mobile/wireless ATM networks. Specific ATM UNI/NNI protocol extensions for location management and handoff control are proposed and described in context of existing ATM networks. The viability of these protocols is established via implementation of a proof-ofconcept prototype mobile ATM network. The prototype system ...
We present and discuss measurements performed with XTPX over the European ATM Pilot. The main characteristic of this wide area ATM network is that the traffic contract is enforced by a Usage Parameter Control (UPC) mechanism. When the ATM traffic is compliant with the traffic contract, XTPX achieves a good utilisation of the link. However, when the ATM traffic is not entirely compliant, the UPC...
Cisplatin induces renal cell injury and death, resulting in nephrotoxicity that limits its use in cancer therapy. Using cell culture models, recent work has suggested the involvement of p53 in renal cell apoptosis during cisplatin treatment. However, the signals upstream of p53 remain elusive. ATM and ATR are critical regulators of p53 under various conditions of DNA damage. Here, we show that ...
The checkpoint kinase ATM (ataxia telangiectasia mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. Here, we report the characterisation of an essential cofactor for ATM, ATMIN (ATM INteracting protein). ATMIN interacts with ATM through a C-terminal motif, which is also present in Nijmegen breakage syndrome (NBS)1. ATMIN a...
There are conflicting reports about the involvement of single nucleotide polymorphisms (SNPs) of the ataxia telangiectasia mutated (ATM) gene with cancer, and the consequences of these SNPs for ATM function remain unclear. We therefore sought to identify SNPs of the ATM gene in pediatric Hodgkin disease (HD) and to analyze ATM function in cells from patients with these SNPs. We have identified ...
Air Traffic Management (ATM) will be more complex in the coming decades due to growth and increased complexity of aviation has improved order maintain safety. It is agreed that without significant improvement this domain, safety objectives defined by international organisations cannot achieved a risk incidents/accidents envisaged. Nowadays, computer science plays major role data management deci...
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