Hematotoxicity in individuals genetically deficient in glucose-6-phosphate 22 dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial 23 drug in clinical use for treatment of relapsing P. vivax malaria. PQ is currently clinically used in 24 its racemic form. A scalable procedure was developed to resolve racemic PQ thus providing pure 25 enantiomers for th...

since it is essential to deliver smoothed sinusoidal voltage to the customers, diagnosing power quality (pq) events has played important role in power delivery and conversion. this diagnostic scheme should be accurate to classify pq events from other events in power system. also it should be fast enough to rapidly mitigate pq events. in this paper, an algorithm based on core vector machine (cvm...

OBJECTIVE This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-β1 (TGF-β1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. METHODS A total of 90 male rats (190-210 g) were randomly and evenly divided into 9 groups: control group, PQ groups (4 gr...

BACKGROUND/AIMS Paraquat (PQ) has been used in suicide attempts; an estimated 2,000 toxic ingestions occur annually, with 60-70% mortality. We sought to determine why PQ is such a common agent for suicide attempts in Korea. METHODS We analyzed 250 cases (143 males, 107 females) of attempted suicide by PQ ingestion from January to December 2007. The procurement of the PQ was divided into two c...

Let Z=(pq) be the integer residue ring modulo pq with odd prime numbers p and q. This paper studies the distinctness problem of modulo 2 reductions of two primitive sequences over Z=(pq), which has been studied by H.J. Chen and W.F. Qi in 2009. First, it is shown that almost every element in Z=(pq) occurs in a primitive sequence of order n > 2 over Z=(pq). Then based on this element distributio...

The mortality rate of acute paraquat (PQ) poisoning depends on the PQ concentration in the blood. It has been shown that the kidneys eliminate PQ effectively. However, early renal function deterioration is frequently observed in acute PQ intoxication. This study is designed to compare the efficacy of PQ elimination with hemoperfusion (HP) and kidneys, taking into account the functional deterior...

Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or var...

Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine...