نتایج جستجو برای: 0051
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Interpretation of trials with drugs and devices; a double standard? Recently, results have been presented of two major trials which, appropriately, received considerable attention in both the professional and lay press. The West of Scotland Coronary Prevention study (WOSCOP) demonstrated a reduction of coronary events at 5-year follow-up through treatment with a cholesterol lowering drug (prava...
Circadian phase and its relation to sleep are increasingly recognized as fundamental factors influencing human physiology and behavior. Dim light melatonin onset (DLMO) is a reliable marker of the timing of the circadian clock, which has been used in experimental, clinical, and descriptive studies in the past few decades. Although DLMO and its relationship to sleep have been well documented in ...
aspirin in cerebral ischemia. Stroke 1977;8:301–314. 43. Swedish C. High-dose acetylsalicylic acid after cerebral infarction. A Swedish Cooperative Study. Stroke 1987;18:325–334. 44. CCSG. A randomized trial of aspirin and sulfinpyrazone in threatened stroke. The Canadian Cooperative Study Group. N Engl J Med 1978;299:53–59. 45. Sorensen PS, Pedersen H, Marquardsen J, Petersson H, Heltberg A, S...
Lind, C. 2017. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1549. 64 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0051-1. The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in tur...
Purpose: Advanced castration-resistant prostate cancer, for which there are few treatment options, remains one of the leading causes of cancer death. MicroRNAs (miRNA) have provided a new opportunity for more stringent regulation of tumor-specific viral replication. The purpose of this study was to provide a proof-of-principle that miRNAregulated oncolytic herpes simplex virus-1 (HSV-1) virus c...
BACKGROUND Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival of these patients. We examined the feasability of using DNA methylation profiles to determine the occult original cancer in cases of cancer of unknown primary. MET...
1. Pu S, Han F, Ge B. Isolation and characterization of methicillin-resistant Staphylococcus aureus strains from Louisiana retail meats. Appl Environ Microbiol. 2009;75:265–7. doi:10.1128/AEM.0111008 2. Weese JS, Avery BP, Reid-Smith RJ. Detection and quantifi cation of methicillinresistant Staphylococcus aureus (MRSA) clones in retail meat products. Lett Appl Microbiol. 2010;51:338–42. doi:10....
The stochastic block model (SBM) is a random graph model with planted clusters. It is widely employed as a canonical model to study clustering and community detection, and provides generally a fertile ground to study the statistical and computational tradeoffs that arise in network and data sciences. This note surveys the recent developments that establish the fundamental limits for community d...
The ultrasound (US) contrast agent, SonoVue®, has been approved for use worldwide. Conversely, Sonazoid®, which was approved in Japan ahead of other countries in January 2007, is also currently used in Korea, China, and Norway, although its use is gradually spreading to other countries. Sonazoid®-enhanced US is considered a breakthrough imaging technology because it has drastically changed clin...
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