While much advancement has been made in breast cancer treatment, metastatic breast cancer remains an incurable disease. MUC1 is a glycoprotein expressed on normal glandular epithelial but is over-expressed and underglycosylated in over 90% of human breast tumors and 100% of metastatic lesions, which lead to its ranking by NCI as the second most targetable antigen. Vaccines against tumor antigen...

We present a new continuous adjoint method for Aerodynamic Shape Optimization (ASO) using the Euler equations, which reduces the computational cost of the gradients by reducing the volume integral part of the adjoint gradient formula to a surface integral. The savings are particularly significant for three-dimensional ASO problems on general unstructured and overset meshes. In order to validate...

Social support and constraint may impact cognitive processing of traumatic or stressful events, thereby influencing adjustment. This study tested a path model accounting for positive and negative affect in male spouses of women with breast cancer (N = 105). The model examined support and constraint from the patient and others, as well as mediators of cancerrelated intrusive thoughts and avoidan...

CONTEXT MEN1 gene alterations have been implicated in lung carcinoids, but their effect on gene expression and disease outcome is unknown. OBJECTIVE Our objective was to analyze MEN1 gene and expression anomalies in lung neuroendocrine neoplasms and their correlations with clinicopathologic data and disease outcome. DESIGN We examined 74 lung neuroendocrine neoplasms including 58 carcinoids...

Scatter Search and its generalized form Path Relinking, are evolutionary methods that have been successfully applied to hard optimization problems. Unlike genetic algorithms, they operate on a small set of solutions and employ diversification strategies of the form proposed in Tabu Search, which give precedence to strategic learning based on adaptive memory, with limited recourse to randomizati...

Purpose Food safety knowledge and hygienic practices by food handlers play an important role in the prevention of contamination prepared. Design/methodology/approach This descriptive survey was conducted Maseru around taxi ranks amongst 48 93 consumers using a semi-structured questionnaire for assessing handler knowledge, attitudes practices, open-ended obtaining consumer perceptions observatio...

Immunosuppressive Drug Monitoring. Ther Drug Monit 2002;24:59–67. 12. Novartis. Neoral C-2 monitoring: scientific evidence and clinical validation. http://www.transplantation-schweiz.ch/e/sandimmun/Scientific_Monograph. pdf (accessed June 2004). 13. Morris RG, Russ GR, Cervelli MJ, Juneja R, McDonal SP, Mathew TH. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclo...

In the final months of the project, we cracked the problem of determining the rate region of the vector Gaussian "one-helper" source coding problem. This problem was one of the most fundamental open problems in information theory, and had withstood repeated attacks by several groups around the world, starting with Liu and Viswanath (2007). The problem is similar to that of determining the capac...

Elderly and frail patients with multiple myeloma (MM) are more vulnerable to the toxicity of combination therapies, often resulting in treatment modifications suboptimal outcomes. The phase 3 BOSTON study showed that once-weekly selinexor bortezomib low-dose dexamethasone (XVd) improved PFS ORR compared standard twice-weekly moderate-dose (Vd) previously treated MM. This is a retrospective subg...