ALX-0681 is a therapeutic Nanobody targeting the A1-domain of von Willebrand factor (vWF). It inhibits the interaction between ultra-large vWF and platelet GpIb-IX-V, which plays a crucial role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP). This study reports the efficacy and safety profile of ALX-0681 in a baboon model of acquired TTP. In this model, acute episodes of TTP ar...

Nature often presents complexities, for example the formyl peptide receptor (FPR) 2/ALX that curiously can mediate either pro-inflammatory or pro-resolution of inflammation responses depending on the ligand it encounters. Formyl peptides originate from bacteria. The formyl peptide receptor may notonly respond to products derived from pathogenic organisms but also from commensals in the intestin...

Climate model simulations available from the PMIP1, PMIP2 and CMIP (IPCC-AR4) intercomparison projects for past and future climate change simulations are examined in terms of polar temperature changes in comparison to global temperature changes and with respect to pre-industrial reference simulations. For the mid-Holocene (MH, 6,000 years ago), the models are forced by changes in the Earth’s or...

There is compelling evidence that interstitial inflammation plays a central role in the loss of renal function in chronic renal disease. The combined effects of interstitial inflammation, oxidative stress and local angiotensin II activity result in the disruption of glomerulus-tubule continuity, the development of pathogenic hypoxia, the generation of myofibroblasts and fibrosis, and the impair...

TOPIC: Critical Care TYPE: Fellow Case Reports INTRODUCTION: Ketamine, a noncompetitive N-methyl-D-aspartate glutamate receptor (NMDAR) antagonist initially developed in 1963 as an anesthetic, has been recently used for analgesia and treatment of asthma depression. Its popularity, resulted increased incidence addiction, especially East Asia United States. Chronic use ketamine affects neurologic...

This paper treats problems with corner singularities« It is shown that if appropriate weights are used in the least squares formulation, then optimal error estimates can be derived in unweighted L2 norms. University Libraries C&rnegie Mellon University Pittsburgh, Pennsylvania 15213 Finite Element Methods of the Least Squares Type for Regions With Corners* G* J. Fix* Carnegie-Mellon University ...

0049: LOCAL ANAESTHETIC TOXICITY: FOCUSED TEACHING IMPROVES SURGEONS’ KNOWLEDGE Usman Khalid , Aeliya Zaidi , Michael Lamyman , Marc Swan . 1 Stoke Mandeville Hospital, Aylesbury, UK; Morriston Hospital, Swansea, UK. Aim: Local anaesthetic (LA) is routinely used by Plastic Surgeons. Toxicity can lead to potentially fatal complications. The aim of this audit was to determine the current awarenes...

capabilities for locating, combining, processing, and organizing information. With the vast number of information resources A promising approach to this problem is to proaviilable today, a critical problem is how to lovide access to the large number of information cate. retrieve and process information. It would sources by organizing them into a network of inbe impractical to build a single uni...

There is compelling evidence that interstitial inflammation plays a central role in the loss of renal function in chronic renal disease. The combined effects of interstitial inflammation, oxidative stress and local angiotensin II activity result in the disruption of glomerulus-tubule continuity, the development of pathogenic hypoxia, the generation of myofibroblasts and fibrosis, and the impair...