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Background GSK is investigating an autologous TCR T-cell therapy for solid tumors that recognizes the cancer testis antigen, NY-ESO-1, presented on cell surface by specific HLA-A*02 sub-types. The aim of this study was to estimate number patients in US 2020 with genotype subtypes HLA-A*02:01, 02:05, 02:06 across selected types (invasive lung, ovarian, gastric, esophageal, invasive and in-situ b...
OBJECTIVE Several studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc patients. Here, we sought to identify HLA alleles associated with SSc in Japanese, and explored their associations with SSc phenotypes incl...
Abstract not available
 Bang Med J Khulna 2021; 54 : 01-02
Draft 2 of 3D-HEVC Test Model Description Ed. Notes (WD2) (based on JCT3V-A1005) Accepted changes and marked delta to base spec (3DC-GT2) Editorial improvements, small corrections (3DC-CY) Editorial improvements, small corrections (MVS-02/JCT3V-B0046) Treatment of inter-view pictures as long termreference pictures (3DE-11) Revised text related to 3Dn-01 (3Dn-01/m23639) Results on mo...
We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain molecules (i.e., appropriate HLA α1α2 H chain domains fused with a mouse α3 domain and covalently linked to human β2-microglobulin). Whereas surface expression of several transgenes was markedly reduced in recipient mice that coexpressed endoge...
In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total...
INTRODUCTION The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls. RESULTS The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01...
Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current study we studied the HLA class I and class II genes in 231 Chinese voluntary b...
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