BACKGROUND Between 20% and 30% of patients with clinically diagnosed hypertension have normal blood pressure (BP) values during automated ambulatory 24-hour BP monitoring. It has not been clear, however, whether these patients can be regarded as normotensive or whether they should be treated in the same way as confirmed hypertensive patients. METHODS AND RESULTS Ambulatory BP monitoring was p...

1269 Reproducibility of individual response to exposure to high altitude The response of people who live at sea level to the low oxygen concentrations at high altitude varies widely. Some people are relatively unaffected while others suffer severe acute mountain sickness.' Anecdotal reports and experiments in decompression chambers have indicated that responses to high altitude are reproducible...

We studied the hemodynamic effects of surgically induced regional cardiac tamponade in anesthetized dogs. Tamponade restricted to either the right or the left ventricle was compared with tamponade of either ventricle and both atria. Intrapericardial pressures were elevated to approximately 20 mm Hg. With tamponade of the right ventricle alone, aortic pressure rose from 161 +/- 3.8 to 164 +/- 3....

Phenyldiazene reacted with lymphoblast-expressed CYP3A4 to give a stable phenyl-iron complex that could be induced to rearrange in situ producing approximately equal amounts of four N-phenyl-protoporphyrin IX isomers (N(B):N(A):N(C):N(D), 01:01:02:02). In the presence of 10 mM MgCl(2), the formation profile of the protoporphyrin isomers was markedly altered compared with control, favoring the N...

PURPOSE To evaluate the prophylactic efficacy of selective laser trabeculoplasty for preventing an increase in intraocular pressure (IOP) after intravitreal triamcinolone acetonide injection. DESIGN Prospective, comparative, interventional case series. METHODS We studied 31 eyes with a baseline IOP of 21 mm Hg or more of 31 patients for which intravitreal triamcinolone acetonide injection w...

This paper reports results from a long-term experiment with a primary objective to increase twinning rate in cattle at the Roman L. Hruska U.S. Meat Animal Research Center. Survival of singles was 13% higher (P < .01) than that of twins at birth, and the difference in survival in favor of singles was of similar magnitude at 72 h (12.9%, P < .01), 150 d (14.8%, P < .01), and 200 d (15.2%, P < .0...

BACKGROUND UCN-01, a Chk1 inhibitor, abrogates S and G(2) arrest and enhances cancer cell killing by DNA-damaging drugs in preclinical models. UCN-01 avidly binds alpha1-acid glycoprotein in plasma; whether sufficient drug concentrations are achieved in human tumors is unknown. A phase I trial tested the hypothesis that UCN-01 abrogates cisplatin-induced cell cycle arrest (in tumors) at tolerab...

We have reported that inhibition of angiotensin-converting enzyme with captopril attenuates the cardiovascular responses to bilateral carotid occlusion in conscious rabbits and proposed that the attenuation results from removal of a facilitatory action of angiotensin II on the sympathetic nervous system. The aim of the present study was to assess the effect of carotid occlusion on renal sympath...

Water is an important asset for the maintenance of life and socioeconomic development. Aquatic environments have been anthropized, receiving a large polluting load, mainly from trace elements.This study investigates occurrence health risks caused by 15 elements in surface water João Leite stream. Health risk indices were evaluated as average daily dose (ADD), hazard quotient (HQ), index carcino...

Most rhinovirus serotypes use intercellular adhesion molecule-1 (ICAM-1) as the receptor to enter cells, but ICAM-1 expression has not been detected on normal nasal epithelial cells. During experimental rhinovirus infection, expression of ICAM-1 on nasal epithelial cells was examined with immunohistochemical staining of nasal scrape biopsy specimens, and levels of soluble ICAM-1 in nasal lavage...