In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Studies in African-Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, ...

Type III effectors play a vital role in the establishment of symbiosis. In this study, positive and negative effects NopT on nodulation were detected 30 soybean germplasms. The quantitative trait loci (QTL) related to nodule number identified their responses recombinant inbred lines chromosome segment substitution evaluated. Ten QTL chromosomes 02, 05, 06, 10, 13. One overlapping region 02 was ...

BACKGROUND & OBJECTIVES Human papillomavirus (HPV) is the main causative agent for cervical cancer. Variability in host immunogenetic factors is important in determining the overall cellular immune response to the HPV infection. This study was carried out to confirm the association between human leukocyte antigen (HLA) class II alleles and cervical cancer in HPV infected women. METHODS Both l...

BACKGROUND Certain HLA class II haplotypes have long been related with the risk of developing type 1 diabetes. The presence of the HLA haplotype DRB1*04/DQA1*03/DQB1*03:02, together with specific β-cell autoantibodies, contributes to the development and/or severity of insulin deficiency in type 1 diabetes. OBJECTIVE To evaluate the association of HLA risk haplotype HLA-DRB1/-DQA1/-DQB1 with β...

Celiac disease (CD) is a chronic inflammatory disease in the small intestine triggered by gluten uptake that occurs in genetically susceptible individuals. HLA-DQ2 protein encoded by HLA-DQA1*05 and DQB1*02 alleles is found in 90-95% of CD patients. All of the remaining patients carry HLA-DQ8 protein encoded by HLA-DQA1*03 and DQB1*03:02 alleles. Specific HLA-DQ genotypes define different risk ...

* This work was supported in part by the US National Institutes of Health grants (1R56AI092497-01A1 to J.B., 5R01CA125162-05 to J.A.J., 5R01AI087630-02 to F.S.S., and 5R01AI088027-02 to K.C), and by the Martin Turkish and the M-O’Connor-Foundation. 1 To whom correspondence should be addressed: Dept. of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Br...

The patient was a 25-year-old woman whose paternal family was Japanese, maternal grandfather was Filipino, and maternal grandmother was Chinese. Eleven days after delivery, she presented with excessive thirst and disturbed consciousness due to diabetic ketoacidosis. She was diagnosed as having fulminant type 1 diabetes associated with pregnancy (PF). The antibody concentration against glutamic ...

Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in 160 antibody positive patients compared 1000 controls. Increased risk was observed for DRB1*10, DRB1*14, DRB1*16 DQB1*05, lower DRB1*04, DRB1*13 DQB1*03. H...

M. Micoulaut,1 M. Malki,2,3 D. I. Novita,4 and P. Boolchand4 1Laboratoire de Physique Théorique de la Matière Condensée, Université Pierre et Marie Curie, Boite 121, 4 Place Jussieu, 75252 Paris Cedex 05, France 2CEMHTI, CNRS, UPR 3079, 1D Avenue de la Recherche Scientifique, 45071 Orléans Cedex 02, France 3Université d’Orléans (Polytech’ Orléans), BP 6749, 45072 Orléans Cedex 02, France 4Depar...