Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta...

INTRODUCTION 3-Methylcholanthrene and eight of its metabolites were tested for tumonigenic activity in two tumor models. In the tumonigenicity study on mouse skin, a single topical application of 3 to 30 nmol of compound was followed 7 days later by twice weekly applications of the tumor promotor i 2-0-tetra decanoylphorbol-i 3-acetate for 30 weeks. Comparisons of the percentage of mice with tu...

INTRODUCTION 3-Methylcholanthrene and eight of its metabolites were tested for tumonigenic activity in two tumor models. In the tumonigenicity study on mouse skin, a single topical application of 3 to 30 nmol of compound was followed 7 days later by twice weekly applications of the tumor promotor i 2-0-tetra decanoylphorbol-i 3-acetate for 30 weeks. Comparisons of the percentage of mice with tu...

Current antimicrobial drug discovery and advancement attempts are aimed to identify new complexes that can work effectively against the infections caused by microbes. The aim of present study was synthesize diorganotin(IV) N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-2-nitrobenzohydrazide (H2L1), N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)m...

In the title compound, C(22)H(16)O, the six-membered ring within the anthrone moiety adopts a shallow boat conformation, with puckering parameters Q = 0.2860 (17) Å, Θ = 99.1 (3)° and Φ = 114.8 (3)°. The dihedral angle between the outer benzene rings is 26.53 (8)°. The mean plane through the anthrone ring system makes a dihedral angle of 38.73 (6)° with the pendant benzene ring. In the crystal,...

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were ...

Eleven new bisresorcinols including four mixtures each of two isomers and one resorcinol/phloroglucinol derivative, together with five known resorcinols have been isolated from the ethyl acetate extract of stems of Grevillea whiteana. The new compounds were identified as 4-(3-hydroxy-3-methylbutyl)grebustol-B (10a), 4'-(3-hydroxy-3-methylbutyl)grebustol-B (10b), 4-(4-hydroxy-3-methylbutyl)grebu...

We adapted the Seliwanoff method to quantify fructose in mosquitoes. This method showed a minimum detection limit of 2.4 microg of fructose, and was more reliable and nearly four times more sensitive than the anthrone test. The Seliwanoffmethod was used to measure the maximum sugar intake by individual mosquitoes and to determine the digestion time of this nutrient by both Aedes aegypti and Aed...

The new major metabolite of @-acetylaminofluorene (AAF) in the rat, N-hydroxy AAF, was excreted in the urine as a conjugate in amounts that increased during car cinogenesis; the amount at 18 weeks was about 9 times that at 1@weeks. When 3methylcholanthrene, which greatly inhibits the carcinogenicity of AM?, was fed with AAF, the excretion of N-hydroxy-AAF remained low, while the excretion of 3a...

The skin tumor-promoting ability of 1,8-dihydroxy-3-methyl-9anthrone (chrysarobin) was compared with that of 12-O-tetradecanoylphorbol-13-acetate(TPA)and 1,8-dihydroxy-9-anthrone (anthralin) in SENCAR mice. Although dose-response compari sons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more p...