The activity of the somatotropic axis was analysed in juvenile rainbow trout (Oncorhynchus mykiss) fed either a fishmeal-based diet (FM) or graded levels of plant proteins to replace 50% (PP50 diet), 75% (PP75 diet) or 100% (PP100 diet) of the fishmeal protein. For this purpose, partial cloning and sequencing of the gene encoding rainbow trout growth hormone receptor (GHR) was first accomplishe...

The auditory and vestibular organs form the inner ear and have a common developmental origin. Insulin like growth factor 1 (IGF-1) has a central role in the development of the cochlea and maintenance of hearing. Its deficiency causes sensorineural hearing loss in man and mice. During chicken early development, IGF-1 modulates neurogenesis of the cochleovestibular ganglion but no further studies...

It is commonly known that the insulin-like growth factor-I gene contains six exons that can be differentially spliced to create multiple transcript variants. Further, there are two mutually exclusive leader exons each having multiple promoter sites that are variably used. The mature IGF-I protein derived from the multiplicity of transcripts does not differ suggesting a regulatory role for the v...

The CSTD Working Group on Improvements to the IGF recognizes the need to improve the format of IGF outcomes to ensure its impact on global internet governance policy issues; recalls the importance of the non-binding and non-duplicative process of the IGF which should be maintained and reflected in IGF outcomes; underlines the full diversity of opinions on policy issues of the IGF multi-stakehol...

In spite of the importance of IGF-I for growth and development, knowledge about regulation of its production in submammalian species is rather limited. In order to create a tool for investigation of direct regulatory effects on the expression of IGF-I in bony fish liver, a primary cell culture of hepatocytes from Oreochromis mossambicus, the tilapia, was established. The cells were viable for u...

This study evaluated the effects of supplying altrenogest from day 6-12 pregnancy on endometrial glandular epithelium, corpora lutea (CL) morphology, and CL gene expression. A total 12 crossbred females (Landrace × Large White) were used. The assigned to 4 treatments according a random design with 2 factorial arrangement, two categories (sow or gilt) (non-treated treated altrenogest). On 6 preg...

Acquired GH resistance together with reduced skeletal muscle mass are found in patients with increased protein catabolism due, for example, to sepsis, trauma, or major surgery. Both administration of glutamine-containing parenteral nutrition and GH treatment have been found to diminish this catabolism. The effects of GH are mediated in part by insulin-like growth factor I (IGF-I) that is produc...