Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations between inflammatory gene polymorphisms and OS risk. Nine studies that met the inclusion criteria were finally recruited in this ...

Protein kinase C (PKC) has been implicated in tumor necrosis factor-alpha (TNF) signaling. Structurally and functionally distinct PKC activators and selective inhibitors of PKC were used to investigate the involvement of PKC isozymes in influencing TNF sensitivity in MCF-7 cells. Activators of PKC, such as phorbol-12, 13-dibutyrate (PDBu) (1.0 microM), indolactam V (10 microM), and bryostatin 1...

chemokines are classified in four distinct groups as cxc, cc, cx3c and c, depending on the presence or absence of a motif called elr (arg-leu-glu) before the first cysteine residue in their structure. cxc chemokines are also subdivided into elr + and elr - . increasing evidence has indicated the existence of a chemokine network in the liver which is involved in both physiological responses and,...

BACKGROUND The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin. METHODS Human adult articular cartilage was obtained from 9 patients (6 male and 3 females), with primary knee osteoarthritis (OA), undergo...

The aims of our study were to investigate association some effect pro- inflammatory and antiinflammatory cytokines before after surgical patients through serum concentration of, TNF-?,IL-2, IL-4, IL-6, IL-10. 35 blood samples collected from (17 male, 18 female)withgeneral anesthesia Al-Diwaniyah Hospital, Iraq. Samples taken surgery (Tpre), the firstday) T1), third day) T3 (and fifth day (T5) o...

Estrogens at physiological concentrations are thought to play an immune-stimulating role, whereas androgens have an anti-inflammatory impact. However, their role on cytokine secretion in the presence or absence of cortisol has not been investigated. Furthermore, the role of hydroxylated estrogens downstream of 17beta-estradiol (E2) on secretion of tumor necrosis factor (TNF) is not known. In th...

Macrophages are induced by LPS to release a number of products that determine the host response during gram negative sepsis. To examine the role of one such substance, tumor necrosis factor (TNF), in mediating LPS-induced injury, we employed a rabbit model of endotoxic shock to (a) determine the kinetics and extent of release of TNF into plasma after injection of LPS, and (b) to evaluate the pr...