esults: Significant linkage for P3 amplitude was observed on chromosome 7q for the central recording site (logarithm-of-odds [LOD] .88, p .00002) and in the same region for both frontal (LOD 2.19, p .0015) and parietal (LOD 1.67, p .0053) sites, with multivariate nalysis also identifying linkage in this region (LOD 2.14, p .0017). Suggestive linkage was also identified on 6p (LODmax 2.49) and 1...

Previously, we reported evidence of genetic heterogeneity in late-onset familial Alzheimer's disease, based on sex of affected parent, demonstrating linkage to chromosome 10q, a region identified by other groups and implicated as a quantitative trait loci for Abeta levels, in families with an affected mother. Using functional magnetic resonance imaging and a memory encoding task, we now show di...

Published data on prognostic and predictive factors in patients with gliomas are largely based on clinical trials and hospital-based studies. This review summarizes data on incidence rates, survival, and genetic alterations from population-based studies of astrocytic and oligodendrogliomas that were carried out in the Canton of Zurich, Switzerland (approximately 1.16 million inhabitants). A tot...

bladder cancer is the most frequent genitourinary malignancy in iran. environmental and genetic factors are the two factors linked with bladder cancer expansion. the aim of this study was to investigate the role of pten gene and environmental risk factors on the progression and prognosis of bladder cancer.we evaluated 55 tumor specimens and 66 bladder mucosa samples of non-cancerous patients be...

A reciprocal chromosome translocation between 7q and 10q and an unrelated Robertsonian translocation involving 14q and 21q were found in a healthy 44-year-old man, in his normal 18-year-old son, and in his mother. They were ascertained through the man's brother, whose grandson has Down's syndrome as a result of an inherited 14q21q translocation. To our knowledge, this is the second report of a ...

Gagap (stuttering) adalah suatu gangguan dalam berbicara yang ditandai dengan terjadinya pengulangan atau perpanjangan dan penghentian bunyi suku kata. dapat diderita oleh segala usia, terutama pada usia anak-anak (developmental stuttering) menyebabkan kefasihan keterlambatan hal berbicara. Insiden seseorang pernah mengalami gagap hidupnya sekitar 5% populasi dunia 60 juta orang. Studi menunjuk...

Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens. The most abundant genetic changes include DNA losses of chromosome arms 3p, 5q, 10q, 13q, and 17p and DNA gains of 3q, 5p, 8q, and 17q. Amplification sites in these tumors were mapped to 22 chromosome bands. The most fr...