The association between schizophrenia and the Ser9Gly variant of the dopamine D3 receptor gene (DRD3) has been the subject of numerous studies. Under meta-analysis this site, or one or more in linkage disequilibrium with it, appears to contribute a small increase to the relative risk of schizophrenia. In this study, 768 bp of the 5 0-leader region of DRD3 mRNA was screened for polymorphisms to ...

Pregnenolone sulfate (PREGS) potentiates the N-methyl-d-aspartate (NMDA) receptor-mediated Ca-signals in cultured hippocampal neurons. The NMDA receptor family has several different subunits whose expression in neurons has distinct spatial and temporal patterns. To examine subunit speci®city of the PREGS action, we have investigated the effect of PREGS on recombinant GluR 12/z1 (NR2B/NR1) type ...

Chronic pain continues to impose a large burden of suffering, yet its neural correlates remain poorly understood. In sympathetically mediated chronic pain (SMP), peripheral sympathetic blockade temporarily relieves this pain, so that related neural activity can be studied without perturbing sensory inputs. We used functional magnetic resonance imaging and thermal painful stimuli applied to the ...

Rats, for 8 weeks consuming the m-opioid agonist etonitazene (forced and free choice conditions yielding high and low drug-consumers), were sacri®ced after 2 days or 6 weeks lasting drug deprivation. Binding characteristics of membranes from the parieto-occipital cortex of these four groups were compared with those of drug-naive controls. In all ®ve groups, 1 mM of the m-opioid receptor agonist...

We describe the effect of the static magnetic ®eld generated by a 0.2 T magnetic resonance tomograph on a normal human neuronal cell culture (FNC-B4). After 15 min exposure cells showed dramatic changes of morphology: they formed vortexes of cells and exposed branched neurites featuring synaptic buttons. At the same time, thymidine incorporation and inositol lipid signaling were signi®cantly re...

We analysed the co-ordination of the elevation angles of the thigh (a t), shank (a s) and foot (a f) during walking in 19 adults and 21 children (aged 11±144 months), including the very ®rst unsupported steps in four. Cross-correlation functions (CCF) maturation of pairs of elevation angles was quanti®ed by a global error parameter (Et(CCF)) re ̄ecting the difference between particular CCF value...

The present experiment examined the effect of aspirin on the escape/avoidance behavioral response to a mechanical stimulus (476 mN von Frey mono®lament) in the place escape avoidance paradigm (PEAP) following subcutaneous administration of carrageenan (CARR). Forty-one male Sprague±Dawley rats received subcutaneous injection of CARR or saline in the left hindpaw and 3 1/2 h later were administe...

Mutations G2370A, G2372A, G2373A, G2375A, Y3937A, S3938A, G3939A and K3940A were made in two potential ATP-binding motifs (amino acids 2370-2375 and 3937-3940) in the Ca(2+)-release channel of skeletal-muscle sarcoplasmic reticulum (ryanodine receptor or RyR1). Activation of [(3)H]ryanodine binding by Ca(2+), caffeine and ATP (adenosine 5'-[beta,gamma-methylene]triphosphate, AMP-PCP) was used a...

Sirkka L. Jarvenpaa a, Noam Tractinsky b and Michael Vitale c a Department of Management Science and Information Systems, CBA 5.202, B6500, University of Texas at Austin, Austin, TX 78712-1175, USA E-mail: [email protected] b Industrial Engineering and Management, Ben-Gurion University, Beer Sheva 84105, Israel E-mail: [email protected] c Melbourne Business School, The University...

The information capacity of the mismatched stationary continuous-time Gaussian channel is determined. The assumptions placed on the signal process are less restrictive than those given in previous treatments. Moreover. Lhe assumptions used may have operational advantages over those used previously. *Department of Statistics. University of North Carolina. Chape] Hill. N.C. 27599-3260 *Department...