Positron emission tomography in combination with the newly introduced catecholamine analogue [11C]hydroxyephedrine ([11C]HED) enables the noninvasive delineation of sympathetic nerve terminals of the heart. To address the ongoing controversy over possible reinnervation of the human transplant, 5 healthy control subjects and 11 patients were studied after cardiac transplant by this imaging appro...

The development of positron tomography and ultra-compact cyclotrons has been accelerating the studies on automated and efficient productions of radiopharmaceuticals labeled with short-lived positron emitters (11C, 13N, 150 and 18F) for medical diagnostic use in hospitalsu. Of these radioisotopes, 11C is the most potential for synthesis of various kinds of organic compounds2). 11CO is one of the...

To characterize externally detectable changes in myocardial metabolism of free fatty acids (FFA) and glucose associated with ischemia, isovolumically beating rabbit hearts were perfused under conditions of selected flows with cyclotron-produced, short-lived (t1/2 - 20.4 minutes), 11C-labeled isotopes of glucose and FFA. Tension-time index decreased 83% and lactate production increased from 0.5 ...

This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional chan...

We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-...

BACKGROUND The aim of this study was to evaluate whether MP [11C]Acetate PET-MRI enables an accurate differentiation of benign and malignant prostate tumors as well as local and distant staging. MATERIALS AND METHODS Fifty-six consecutive patients fulfilling the following criteria were included in this IRB-approved prospective study: elevated PSA levels or suspicious findings at digital recta...

Vitamine B1 thiamine is an essential component for glucose metabolism and energy production. The disulfide derivative, tetrahydrofurfuryl (TTFD), more absorbent compared to readily-available water-soluble salts since it does not require the rate-limiting transport system required absorption. However, detailed pharmacokinetics of TTFD under normal pathological conditions were clarified yet. Rece...

Our study demonstrated that intraprostatic [11C]choline uptake in the 11 analyzed prostate cancer patients significantly declined during and after ebrt. The pet parameters SUVmax and tmr also declined significantly. These effects can be detected during radiation therapy and up to 1 year after therapy. The prognostic value of these early and statistically significant changes in intraprostatic [1...

2 Radiotracers ......................................................................... 16 2.1 11C-Choline, 18F-Choline .................................................... 16 2.2 11C-Acetate ........................................................................... 16 2.3 18F-Fluorodeoxyglucose (FDG) ........................................... 17 2.4 18F-Fluoride ...............................

The 11C-labeled tracer meta-hydroxyephedrine (11C-HED) is a noradrenaline analog that was developed to visualize the sympathetic nervous system with PET. Initial clinical studies show a rapid uptake of 11C-HED in localized tumors of this system. Whole-body imaging with 11C-HED PET is now possible as PET/CT scanners allow a rather short examination time. The aim of this study was to evaluate the...