BACKGROUND MicroRNAs (miRNAs) are widely studied non-coding RNAs that modulate gene expression. MiRNAs are deregulated in different tumors including gastric cancer (GC) and have potential diagnostic and prognostic implications. The aim of our study was to determine miRNA profile in GC tissues, followed by evaluation of deregulated miRNAs in plasma of GC patients. Using available databases and b...

We aimed to evaluate the regulatory effects of miR-148a-3p on stem cell osteogenic differentiation and enamel development by targeting runt-related transcription factor 2 (RUNX2) E-cadherin, respectively. TargetScan software was utilized predict binding sites between marker gene RUNX2 or E-cadherin. The changes in expression during epidermal cells were detected. After transfection with mimics i...

Great interest persists in useful prognostic and therapeutic targets in glioblastoma. In this study, we report the definition of miRNA (miR)-148a as a novel prognostic oncomiR in glioblastoma. miR-148a expression was elevated in human glioblastoma specimens, cell lines, and stem cells (GSC) compared with normal human brain and astrocytes. High levels were a risk indicator for glioblastoma patie...

BO O K O F A BS TR A C TS 53 BO O K O F A BS TR A C TS 52 Introduction. Colorectal cancer is one of the leading causes of death in the world and early detection of colorectal cancer is necessary for the successful treatment. Environmental factors and genetic mutations are involved in the initiation and progression of this disease. MicroRNAs are new molecular markers that could be used both in d...

Introduction: We previously performed global miRNA expression profiling of cHL vs. non-Hodgkin lymphoma (NHL) cell lines and sorted germinal centre B-cells (GCB). In the group 79 deregulated miRNAs (p < 0.05) we became particularly interested in upregulated miR-23a-3p, a potential oncomiR, predicted to regulate TNFAIP3 downregulated miR-148a-3p, tumor suppressor miRNA, IL15. Therefore, aimed de...

OBJECTIVES Acute viral myocarditis (VM) is an important cause of sudden cardiac death and heart failure in healthy young person. Its pathogenesis is based on an adverse immune response evoked by infection of the cardiac muscle by cardiotropic viruses especially Coxackievirus B3 (CVB3). MicroRNAs (miRNAs) are short, noncoding RNA sequences that regulate gene expression at the posttranscriptional...

HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects the EVT cells from immune rejection and is therefore important for a healthy pregnancy. The mechanisms controlling HLA-G expression are largely unknown. Here we demonstrate that miR-148a and miR-152 down-regulate HLA-G ...

BACKGROUND Altered miR-148/152 family expression contributes to human carcinogenesis. This study was designed to detect the potential for using miR-148/152 family as biomarkers for NSCLC patients. MATERIAL/METHODS The relative expression levels of miR-148/152 family (miR-148a, miR-148b, and miR-152) in serum of 36 non-small-cell lung carcinoma (NSCLC) patients, 20 patients with benign pulmona...

Sommario Il diabete mellito di tipo 2 (DMT2) è una malattia metabolica cronica eterogenea in costante aumento. In questa rassegna, al fine identificare un gruppo microRNA (miRNA) con potenziale applicazione clinica come biomarcatori per la diagnosi, prognosi e selezione terapie personalizzate i pazienti DMT2, abbiamo effettuato ricerca sistematica letteratura, identificando selezionando 10 miRN...