Polycystic ovary syndrome (PCOS) is the most common endocrine disorder associated with metabolic disorders and infertility. Evidence suggests that the adipose tissue secreted products, adipokines, play an important role in the pathophysiology of PCOS. Reciprocally, PCOS influences on the adipokines serum content, also on gene or protein expression of some of them. Finding out of assoc...

INTRODUCTION Polycystic ovary syndrome is a common endocrine disorder affecting women both physically and psychologically and can lead to a poor quality of life compared to their normal counterparts. The aim of the present study was to assess the impact of various clinical features of polycystic ovary syndrome on the health-related quality of life of Iranian women diagnosed with this syndrome. ...

Background: Genetic polymorphism is responsible for variations and individual differences. Polymorphism is a major factor of complex diseases with unknown etiology and cancer. Inconsistency in the symptoms of polycystic ovary syndrome (monthly disorder, hirsutism, obesity, diabetes, infertility) is one of the major pathological complications of this syndrome. The present study was conducted to ...

1 Diamanti-Kandarakis E, Papavassiliou AG. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med 2006; 12: 324-332. 2 Azziz R, Carmina E, Dewailly D, et al. Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society Guideline. J Clin Endocrinol Metab 2006; 91: 4237-4245. 3 Teede H, Zoungas S, Hutchiso...

OBJECTIVE To evaluate the association between androstenedione, testosterone, and free testosterone and metabolic disturbances in polycystic ovary syndrome. METHODS We analyzed the association between androstenedione, testosterone, and free testosterone and metabolic parameters in a cross-sectional study including 706 polycystic ovary syndrome and 140 BMI-matched healthy women. Polycystic ovar...

OBJECTIVES The pelvic floor muscles are sensitive to androgens, and due to hyperandrogenism, women with polycystic ovary syndrome can have increased mass in these muscles compared to controls. The aim of this study is to compare reports of urine leakage and quality of life between women with and without polycystic ovary syndrome. METHODS One hundred thirteen 18-to 40-year-old nulliparous wome...

This guideline has been produced to provide information, based on clinical evidence, to assist clinicians with a special interest and for updating the generalist who manages women with polycystic ovary syndrome, to allow them to advise women about the long-term health consequences of the syndrome. This guideline does not cover infertility associated with polycystic ovary syndrome (PCOS), which ...

Metformin in therapy naı¨ve patients with polycystic ovary syndrome Sir, We have read with great interest the paper by Moll et al. (2007) recently published on Human Reproduction Update. The aim of this systematic review was to assess the efficacy of metformin administration in the total spectrum of treatment possibilities for polycystic ovary syndrome (PCOS) patients in terms of fertility impr...

background: polycystic ovary syndrome (pcos) is a heterogeneous complex genetic disorder characterized by hyperandrogenemia hyperinsulinemia insulin resistance and chronic anovulation. it is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis. obesity hyperandrogenism and infertility occur frequently in pcos which mostly have a ...