Introduction Figure 1 summarizes some key aspects of the bovine estrous cycle. Changes in the 2 key structures on the ovary, the preovulatory follicle and the corpus luteum, are emphasized in this figure. The function of 4 important hormones is also summarized in this figure. Estradiol-17ß from the preovulatory follicle causes the cow to manifest estrus behaviour and have an LH surge. The LH su...

In the present study, changes of values of serum 17ß-estradiol (E2), Asparate amino teransferase (AST), Alanine amino transferase (ALT) and Lactate dehydrogenase (LDH) following intraperitoneal (i.p) injection with the aromatase inhibitor (AI) letrozole were investigated in rainbow trout (Oncorhynchus mykiss). Forty- eight apparently healthy rainbow trout (mean weight of 845 g) divided...

background: the purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (fet) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch. methods: in this randomized controlled trial, women underwent either conventional ivf or intracytoplasm...

INTRODUCTION AND OBJECTIVES Chagas is an endemic disease in Latin America, caused by the parasite Trypanosoma cruzi, which usually affects the functioning of the heart. We have studied the regulation of intracellular calcium in cardiomyocytes isolated from chagasic patients with different degrees of heart dysfunction. METHODS Calcium selective microelectrodes were used to simultaneously measu...

Female sex steroid hormones, estradiol-17β (E2-17β) and progesterone (P4) regulate reproductive function and gene expression in a broad range of tissues. Given the central role of the liver in regulating homeostasis including steroid hormone metabolism, we sought to understand how E2-17β and P4 interact to affect global gene expression in liver. Ovariectomized cows (n = 8) were randomly assigne...

In order to characterize the endocrine changes associated with ovarian function and pregnancy in wild redfronted lemurs (Eulemur fulvus rufus), profiles of immunoreactive 5α-pregnane-3α-ol-20-one (5-P-3OH) and total estrogens (E t) in feces were generated during the breeding season and gestation. HPLC data confirmed the presence of high amounts of 5-P-3OH in the feces of redfronted lemurs and s...

Cows (n = 21), dried off for a minimum of 45 days, and nulliparous heifers (n = 26), at ages > 18 months old, were placed on a 12-day Lactation Induction (LI) protocol. One group of animals (including both cows and heifers) received 3-minute mammary gland stimulation, along with the LI protocol. Another group, again including both cows and heifers, received no stimulation. Only the LI protocol ...

The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival during the acute radiation syndrome (ARS) in mice and non-human primates. 5-AED promotes survival of irradiated human hematopoietic progenitors in vitro through induction of Nuclear Factor-κB (NFκB)-dependent Granulocyte Colony-Stimulating ...

Uterine leiomyomas (ULM) are a common cause of solid pelvic tumors in women. Their etiopathogenesis remains unclear. Interleukins (ILs) and their receptors can influence tumor biology of ULM. The aim of this study was to evaluate single nucleotide polymorphisms (SNPs) exhibited in the genes IL4 (rs2070874), IL4R (rs1801275), IL12RB1 (rs11575934), IL12B (rs6887695), IL13 (rs20541) and IL23R (rs7...

BACKGROUND AND RATIONALE The control of Endothelin-1 (ET-1)-mediated intrahepatic vasoconstriction in cirrhosis is beneficial for the alleviation of relevant complications. Cirrhosis is accompanied by hypogonadism and altered sex hormone status. Besides, sex hormones have vasoactive effects, but it is unknown if they influence vascular function in cirrhosis. This study aimed to investigate the ...