In my prosopographic examination of new aristocrats in the eighteenth century, I came across Georg Wolfgang Chiolich, an atypical member this group, as he was only one to receive title baron for himself alone, a bishop, during century. What point conferring noble on bishop? Searching reply question, we can gain some insight into social, economic, and especially political processes Habsburg Empi...

O ano de 1764 assinala o surgimento do romance gótico com a publicação castelo Otranto, Horace Walpole. Confrontando os valores Iluminismo da época, Walpole estabelece pressupostos que se constituirá como um dos mais duradouros gêneros ficção ocidental. A presença História é essencial tanto para gênero quanto modo gótico, trazendo elemento passado assombra presente na modernidade, partir cenári...

The basal core promoter (BCP) of hepatitis B virus (HBV) directs the transcription of both precore RNA and core RNA which code for e antigen (HBeAg) and core antigen, respectively. A double mutation in the BCP which converts nucleotide (nt) 1762 from A to T and nt 1764 from G to A is frequently observed in patients with chronic hepatitis B. We recently demonstrated that this double mutation pre...

The tricyclic anticonvulsant drugs phenytoin, carbamazepine, and lamotrigine block neuronal voltage-gated Na(+) channels, and their binding sites to domain IV-S6 in the channel's inner pore overlap with those of local anesthetic drugs. These anticonvulsants are neutral, in contrast to the mostly positively charged local anesthetics, but their open/inactivated-state blocking affinities are simil...