Angel Rubio‡ University of the Basque Country UPV/EHU, Nano-Bio Spectroscopy Group, Avenida de Tolosa 72, 20018 San Sebastian, Spain and Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany. Center for Free-Electron Laser Science and Department of Physics, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany (Dated: September...

Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the Ca(v)2.3 channel by profoundly shifting its voltage-dependent gating. We show that zinc and copper, at physiologically relevant concentrations, occupy an extracellular binding site on the surface of Ca(v)2.3 and hold the threshold for activation of these channels in a depolarized vo...

The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 (1 microM), an increase in [Ca2+]i signal was initiated. Concurrent superfusion of either L-364,718 (0.1 microM) or lorglumide (10 microM), chemically distinct, specific, pot...

The well known conjugate gradient algorithm (cg-algorithm), introduced by Hestenes & Stiefel, [1952] intended for real, symmetric, positive definite matrices works as well for complex matrices and has the same typical convergence behavior. It will also work, not generally, but in many cases for hermitean, but not necessarily positive definite matrices. We shall show, that the same behavior is s...

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925-Pos Novel Visualisation Techniques for Localisation Microscopy David Baddeley, Isuru D. Jayasinghe, Sabrina Roßberger, Mark B. Cannell, Christian Soeller. University of Auckland, Auckland, New Zealand. Localisation microscopy techniques based on localising single fluorophore molecules now routinely achieve accuracies better than 30 nm. Unlike conventional optical microscopy approaches, loca...

The new book, The Gender of Reparations: Unsettling Sexual Hierarchies While Redressing Human Rights Violations, edited by Ruth Rubio-Marín, is a powerful interdisciplinary exploration of gendered reparations in transitional countries. Through a gendered perspective, it not only dives deep into the human rights violations experienced by women, it also endeavors to present “engendered” reparatio...

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This article contains data on the single nucleotide polymorphisms (SNPs) rs1137115, rs1801272 and rs28399433 rs4105144 in CYP2A6 associated to smoking related variables in Mexican Mestizo smokers (Pérez-Rubio et al., 2017) [1]. These SNPs were selected due to previous associations with other populations. Mexican Mestizo smokers were classified according their smoking pattern. A genetic associat...

Catalina Dussaillant ([email protected]) Valentina Serrano ([email protected]) Alberto Maiz ([email protected]) Susana Eyheramendy ([email protected]) Luis Rodrigo Cataldo ([email protected]) Matías Chávez ([email protected]) Susan V Smalley ([email protected]) Attilio Rigotti ([email protected]) Lorena Rubio ([email protected]) Carlos F Lagos ([email protected]) José A Martinez (jalfm...