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Cefpodoxime proxetil (CP) is a prodrug with poor oral bioavailability because of its metabolism to Cefpodoxime acid (CA) in luminal contents and intestinal epithelial cells. In the present investigation, regional variability in different segments of the gastrointestinal tract vis-à-vis solubility and metabolism were investigated, and the results indicated potential for a gastro retentive (GR) d...

1 Marine Spatial Ecology Laboratory, School of Biosciences, Hatherly Laboratory, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK; 2 National Center for Ecological Analysis and Synthesis, University of California–Santa Barbara, 735 State Street, Suite 300, Santa Barbara, CA 93101, USA; 3 Hopkins Marine Station, Stanford University, Oceanview Boulevard, Pacific Grove, CA 93950-309...

Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-labeled OVA was injected into the footpad of OVA/CFA immunized mice, the main ...