OBJECTIVE To evaluate CAT-192, a recombinant human antibody that neutralizes transforming growth factor beta1 (TGFbeta1), in the treatment of early-stage diffuse cutaneous systemic sclerosis (dcSSc). METHODS Patients with SSc duration of <18 months were randomly assigned to the placebo group or to 1 of 3 CAT-192 treatment groups: 10 mg/kg, 5 mg/kg, 0.5 mg/kg. Infusions were given on day 0 and...

In this paper we present two new attacks on round reduced versions of the AES. We present the first application of the related-key boomerang attack on 7 and 9 rounds of AES-192. The 7-round attack requires only 2 chosen plaintexts and ciphertexts and needs 2 encryptions. We extend our attack to nine rounds of AES-192. This leaves to a data complexity of 2 chosen plaintexts and ciphertexts using...

PHYSICAL EXAMINATION At the start it is very important to evaluate the vital signs of toxic-appearing patients with rashes. Fever and hypotension are of particular concern and mandate expedited and intensive care. A complete examination should include evaluation for any new-onset heart murmur, changes in mental status, and nuchal rigidity. Of particular importance are the onset and progression ...

BACKGROUND The main cause of death in medulloblastoma is recurrence associated with leptomeningeal dissemination. During this process, the role of microRNAs (miRs) in the acquisition of metastatic phenotype remains poorly understood. This study aimed to identify the miR involved in leptomeningeal dissemination and to elucidate its biological functional mechanisms. MATERIALS AND METHODS We ana...

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle tissues. Of these, miR-192 was found to be up-regulated in prenatal skeletal muscle, but was down-regu...

Pathogenic role of p53 in AKI remains controversial and the underlying mechanism is unclear. Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI). Mice with p53 knock out (p53-KO) were resistant to VAN induced AKI, indicated by the analysis of renal function, histology, and apoptosis. Mechanistically, AKI was associated with the upregul...

PURPOSE We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. EXPERIMENTAL DESIGN Recombinant human VEGI-192 was produced in Escherichia coli and purified to apparent homogeneity. The protein was given systemically via i.p., i.v., or s.c. injections to tumor-bearing C57BL/6 mice. Tumor growth ra...

Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G(1) arrest by down-regulating multiple cell cycle-related transcripts. Here we show that genotoxic stress promotes the p53-dependent up-reg...

Lipoprotein T (LppT), a membrane-located 105-kDa lipoprotein of Mycoplasma conjunctivae, the etiological agent of infectious keratoconjunctivitis (IKC) of domestic sheep and wild Caprinae, was characterized. LppT was shown to promote cell attachment to LSM 192 primary lamb joint synovial cells. Adhesion of M. conjunctivae to LSM 192 cells is inhibited by antibodies directed against LppT. The RG...

The AES block cipher has a 128-bit block length and a user key of 128, 192 or 256 bits, released by NIST for data encryption in the USA; it became an ISO international standard in 2005. In 2008, Demirci and Selçuk gave a meet-in-the-middle attack on 7-round AES under 192 key bits. In 2009, Demirci et al. (incorrectly) described a new meetin-the-middle attack on 7-round AES under 192 key bits. S...