نتایج جستجو برای: 1b
تعداد نتایج: 23152 فیلتر نتایج به سال:
The reaction of KSeO(t)Bu with 2-iodo-arylbenzamides gave benzamide ring-substituted, quinine-derived isoselenazolones 1b–1d. The reaction of PhSH with ortho-methyl-substituted isoselenazolone 1b gave selenol 3b, which is oxidized by H2O2 to regenerate 1b. Isoselenazolone 1b shows a high rate (0.33 × 103 μM min(−1)) of oxidation of PhSH with H2O2, which is ∼103-fold more active than ebselen (1a...
BACKGROUND/AIMS There is some controversy regarding whether or not hepatitis C virus (HCV) subtype 1b is more influential than non-1b subtypes on the progression of chronic hepatitis (CH) C to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). METHODS We retrospectively analyzed 823 patients with chronic HCV infection, including 443 CH patients, 264 LC patients, and 116 HCC patients, wh...
BACKGROUND aPKC and PAR-1 are required for cell polarity in various contexts. In mammalian epithelial cells, aPKC localizes at tight junctions (TJs) and plays an indispensable role in the development of asymmetric intercellular junctions essential for the establishment and maintenance of apicobasal polarity. On the other hand, one of the mammalian PAR-1 kinases, PAR-1b/EMK1/MARK2, localizes to ...
Jedrzkiewicz, Sean, Hidetoshi Nakamura, Eric S. Silverman, Andrew D. Luster, Naresh Mansharamani, Kwang Ho In, Gen Tamura, and Craig M. Lilly. IL-1b induces eotaxin gene transcription in A549 airway epithelial cells through NF-kB. Am J Physiol Lung Cell Mol Physiol 279: L1058–L1065, 2000.—Eotaxin is an asthma-related C-C chemokine that is produced in response to interleukin-1b (IL-1b). We detec...
Much recent work has focused on Americans’ positive and negative feelings toward their own opposing political parties. However, there is neither a consensus how to model such partisan affect, nor detailed understanding of its consequences for participation. This addressed these two gaps by first, empirically examining many dimensions best characteriz...
PURPOSE XAGE-1 was originally identified by the search for PAGE/GAGE-related genes using expressed sequence tag database and was shown to exhibit characteristics of cancer/testis-like antigens. Four transcript variants XAGE-1a, XAGE-1b, XAGE-1c, and XAGE-1d have been identified thus far. We recently identified XAGE-1b as a dominant antigen recognized by sera from lung adenocarcinoma patients. W...
The role of breast cancer resistance protein (Bcrp) and the combined activities of Bcrp and P-glycoprotein (P-gp, Mdr1a/1b) in limiting the brain penetration of drugs at the blood-brain barrier (BBB) were investigated using wild-type FVB, Mdr1a/1b(-/-), (-/-), Bcrp(-/-), and Mdr1a/1b(-/-), (-/-)Bcrp(-/-) mice. Four drugs, flavopiridol, imatinib mesylate (Gleevec), PF-407288, and prazosin, with ...
پیش زمینه و هدف: سندرم متابولیک فاکتور خطر بالقوه ای برای اختلالات قلبی عروقی و آترواسکلروز است، که بواسطه برخی تغییرات فیزیولوژیک و متابولیک ازجمله افزایش تری گلیسیرید، کاهش hdl-c، افزایش ldl-c، افزایش fbs مشخص می گردد. کلستریل استر ترانسفر پروتئین (cetp)، انتقال لیپیدهای خنثی و فسفولیپیدها را بین لیپوپروتئین ها، کاتالیز می نماید. بنابراین، این پروتئین احتمالاً می تواند در تعدیل میزان پلاسمایی ...
Nascent bipolar outflows associated with the first hydrostatic core candidates Barnard 1b-N and 1b-S
HNF-1b mutations. Most importantly, patients with an HNF-1b mutation may also be at risk of developing renal cell carcinomas, since recent evidence suggests that HNF-1b is a tumour suppressor gene [5]. In conclusion, patients with unexplained nephropathy and/or renal cysts should be routinely screened for an HNF-1b mutation in order to differentiate the RCAD syndrome from diabetic nephropathy. ...
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