To investigate the physiological role of the alpha(1D)-adrenergic receptor (alpha(1D)-AR) subtype, we created mice lacking the alpha(1D)-AR (alpha(1D)(-/-)) by gene targeting and characterized their cardiovascular function. In alpha(1D)-/- mice, the RT-PCR did not detect any transcript of the alpha(1D)-AR in any tissue examined, and there was no apparent upregulation of other alpha(1)-AR subtyp...

compound n2, n3, n7, n8, 1, 4, 5, 6, 9, 10-decaphenyltetradecahydrodipyrazino [2, 3-b: 2, 3-e] pyrazine-2, 3, 7, 8-tetraamine (4) was prepared by condensation of 1, 1′, 2, 2′-tetrakis (phenylamino) ethane (1d) and glyoxal in etoh or i-proh. also, reaction of 1d with glyoxal in equimolare in etoh resulted 5,6-bis (ethoxy)-n2, n3, 1, 4-tetraphenylhexahydro-2, 3-pyrazinediamine (5). the natures of...

Integrins play a pivotal role in proliferation, differentiation, and survival in skeletal and cardiac myocytes. The beta(1D)-isoform of the beta(1)-integrin is specifically expressed in striated skeletal muscle. However, little is known about the role and the mechanisms by which the splice variant beta(1D)-integrin regulates myogenesis and mechanotransduction. We observed that cyclic mechanical...

Due to the enhanced piezoelectric properties, excellent mechanical properties and tunable electric properties, one-dimensional (1D) piezoelectric materials have shown their promising applications in nanogenerators (NG), sensors, actuators, electronic devices etc. To present a clear view about 1D piezoelectric materials, this review mainly focuses on the characterization and optimization of the ...

In this paper, the thermal analysis of a membrane antenna structure is performed, and then, rigid-flexible coupling dynamic modeling control membrane-antenna-satellite system are studied with stress considered. The model derived based on finite element method by discretizing into 1D 2D elements. Considering stress, vibration modes obtained, hybrid coordinate method. To reduce caused attitude ma...

Arabidopsis (Arabidopsis thaliana) suppressor of npr1-1, constitutive1 (snc1) contains a gain-of-function mutation in a Toll/interleukin receptor-nucleotide binding site-leucine-rich repeat Resistance (R) protein and it has been a useful tool for dissecting R-protein-mediated immunity. Here we report the identification and characterization of snc4-1D, a semidominant mutant with snc1-like phenot...