BACKGROUND A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. METHODS We used 1H NMR spectroscopy to study serum and urine from the patient. RESULTS The concentration of N, N-dimethylglycine (DMG) was increased approximately 100-fold in the se...

A one-pot synthesis of osmium(IV) complexes with two different tautomers of indazole, 1H-indazole and 2H-indazole, namely (H(2)ind)[Os(IV)Cl(5)(2H-ind)] (1) and (H(2)ind)[Os(IV)Cl(5)(1H-ind)] (2) is reported. Both compounds have been comprehensively characterized by NMR spectroscopy, ESI (electrospray ionization) mass spectrometry, electronic absorption spectroscopy, IR spectroscopy, cyclic vol...

D. Coman, G. Kiefer, D. L. Rothman, D. A. Sherry, and F. Hyder Diagnostic Radiology, Yale University, New Haven, CT, United States, Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States, Macrocyclics, Dallas, TX, United States, Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States, Advanced Imaging Resear...

The title compound, i.e., [RuCl2(η6-p-cymene)(PPh2NHnPr)] (2), was obtained in a 71% yield by reacting toluene solution of the chlorophosphine complex [RuCl2(η6-p-cymene)(PPh2Cl)] (1) with two equivalents n-propylamine at room temperature. aminophosphine 2 characterized elemental analysis, multinuclear NMR (31P{1H}, 1H and 13C{1H}) IR spectroscopy. In addition, its catalytic behavior hydration ...

The title compound, 1-phenyl-3,3-di(1H-pyrazol-1-yl)propan-1-one, was synthesized in a 52% yield for the first time by one-step reaction between 1H-pyrazole and 1-phenylprop-2-yn-1-one (their ratio being 2:1) solid Al2O3 at room temperature. product characterized 1H-NMR, 13C-NMR, IR spectroscopy, X-Ray diffraction elemental analysis.

ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length-based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard. The performance of the PULCON method was assessed using maleic acid (MA). Quantification of the diarrhetic shellfish toxin and okadaic acid by PULCON was successfully consistent with that obtained ...

The title compound, 4-amino-5-benzoyl-1-benzyl-2-(4,5,6,7-tetrahydro-1H-indol-2-yl)- 1H-pyrrole-3-carbonitrile, was synthesized for the first time in a 40% yield by reaction of N-benzyl-3-imino-5,6,7,8-tetrahydro-3H-pyrrolo[1,2-a]indol-1-amine and 1-chloroacetophenone K2CO3/MeCN system (reflux, 6 h). product characterized 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis.

Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel–Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate. The structure of the newly compound elucidated 1H-NMR, 13C-NMR, NOESY-1D, ESI-MS, FT-IR, UV-Vis spectroscopy.