The asymmetric unit of the title salt, C8H10N5 (+)·C7H7O3S(-), consists of two amino-[(1H-benzimidazol-2-yl)amino]-meth-an-im-inium cations and two 4-methyl-benzene-sulfonate anions. The cations are each stabilized by intra-molecular N-H⋯N hydrogen bonds between the free amino groups and the imine N atoms of the benzimidazole units, forming S(6) ring motifs. In the crystal, cations and anions a...

There are two independent mol-ecules in the asymmetric unit of the title compound, C(20)H(23)N(3)O, in which the dihedral angles between the phenyl ring of the phenyl-ethyl-amino group and the benzimidazole system are 73.98 (15) and 15.93 (16)°. The crystal packing features N-H⋯O and N-H⋯N hydrogen bonds.

We amplified, cloned, and sequenced the beta-tubulin gene of Vittaforma corneae, a microsporidium causing human infections. The beta-tubulin gene sequence has a substitution at Glu(198) (with glutamine), which is one of six amino acids reported to be associated with benzimidazole sensitivity. Benzimidazoles were assayed for antimicrosporidial activity and showed poor parasite inhibition.

In the title solvated benzimidazole compound, C(20)H(15)N(3)O(2)·C(2)H(6)OS, both the benzimidazole fused-ring system and the complete dimethyl sulfoxide solvent mol-ecule are disordered over two sets of sites, in 0.750 (5):0.250 (5) and 0.882 (4):0.118 (4) ratios, respectively. The conformation of the pyrimidine ring is close to a half-chair for the major disorder component, whereas for the mi...