The feeding of p-aminobenzoic or cr-amino-y-phenylbutyric acid to rats results in the excretion of acetylaminobenzoic or acetylphenylaminobutyric acid in the urine. Simultaneous feeding of isotopically labeled compounds such as acetic or pyruvic acid (1, 2), Dor L-alanine (3), Dor L-serine (4), or an acetylaminol acid (5) gives rise to labeled acetyl groups. Whereas most combinations of acetyl ...

According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...

OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the synthesis of a novel series of α-ketoamide derivatives (4-[2-(2-acetylaminophenyl)-2-oxo-acetylamino]benzoyl amino acid ester derivatives). OxymaPure showed clear superiority to HOBt/DIC or carbodiimide alone in terms of purity and yield. The title compounds were synthe...

Sloane, Crane, and Mayer (2) reported that Mycobacterium smegmatis oxidizes aniline to p-aminophenol. It was also shown (2) that p-aminobenzoic acid (PABA) yields p-aminophenol after the PABA is first enzymatically decarboxylated to aniline. It is the purpose of this publication to present data on the effect of pH, citrate, inorganic ions, and inhibitors on this hydroxylation reaction. The data...

In situ product recovery (ISPR), in the form of an extractive fermentation process, can increase productivity and titers sustainable production platform chemicals. To establish a guideline for development industrially relevant processes such bio-based compounds, wide screening was performed, mapping potential extensive range solvents solvent mixtures. Besides biocompatibility with Saccharomyces...

Sulphanilamide inhibition of the growth of certain yeasts and yeastlike organisms was overcome in a non-competitive manner by methionine, adenine and histidine, which are therefore regarded as end-products of enzyme systems for which p-aminobenzoic acid is essential. The methionine system was the most sensitive to sulphanilamide, followed in order by those of adenine and histidine. In the prese...

The extensive pharmacological applications of the pyrazole-based compounds stimulated us to synthesize highly functionalized, pyrazolylmalonyl diisothiocyanate derivative (2) via treating 2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)malonyl dichloride (1) with ammonium thiocyanate in acetonitrile at room temperature. 2 was subsequently conducted a double molar ratio different nitrogen nucleophile...