OBJECTIVE To evaluate the clinical literature on cyclooxygenase-2 (COX-2) inhibitors to determine whether a greater incidence of thromboembolic events is universal within the drug class. DATA SOURCES A MEDLINE search was conducted (1996-March 2005) for key articles in the English language assessing the efficacy or safety of these agents. STUDY SELECTION AND DATA EXTRACTION Randomized, doubl...

BACKGROUND Studies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population. METHODS The databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, ...