OBJECTIVES The human papillomavirus (HPV) immunisation programme in England was introduced in 2008. Monitoring changes in type-specific HPV prevalence allows assessment of the population impact of this vaccination programme. METHODS Residual vulva-vaginal swab specimens were collected from young sexually active women (aged 16-24 years) attending for chlamydia screening across England. Specime...

The anti-inflammatory and cytoprotective tricyclic title compound, C(21)H(18)N(2)O(2), also known as TBE-31, crystallizes with two nearly superimposable mol-ecules in the asymmetric unit. In both mol-ecules, the three ring systems conform to an envelope-chair-planar arrangement. The central ring, in a cyclohexane chair conformation, contains an axial ethynyl group that bends slightly off from a...

at -78 "C for 4 h. To the mixture was added a solution of compound 14 (5.0 mmol) and AlCl, (5.0 mmol) in CH2C12 (15 mL) dropwise. The mixture was stirred at -78 "C for 4 h and allowed to warm to room temperature. The mixture was hydrolyzed with water and extracted three times with ether. The ether phase was washed with brine, dried (MgSO,), and filtered. The filtrate was evaporated and the resi...