Following the observation tha t the non-ball-rolling dung beetle Pachylomerus fem oralis (K irby) rolled the flesh-covered seeds from the fruit o f the spineless m onkey orange tree, Strychnos madagascariensis Poiret, an investigation into the chemical a ttrac tan ts o f this fruit was made. U sing headspace gas chrom atography with electroantennographic and flame ioni­ zation detection in para...

Thioredoxin-1 (Trx-1), an important redox regulatory factor, plays a significant role in drug-induced apoptosis. Here we investigated the effects of the Trx-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) on human acute myeloid leukemia cells (AML) and the sensitivity of cells to arsenic trioxide (As2O3, ATO). Treatment of cells with a different concentration of PX-12 for 48 h resulte...

The carboxylic acid functional group of ibuprofen [alpha-methyl-4-(2-methylpropyl) benzene acetic acid] is reduced to the corresponding alcohol and subsequently esterified to the acetate derivative by cultures of Nocardia species strain NRRL 5646. The alcohol and ester microbial transformation products were isolated, and their structures were determined by H and C nuclear magnetic resonance spe...

Isothermal titration calorimetry (ITC) experiments were performed for investigation of binary mixtures comprised the Brønsted superbase DBN with hydrogen ethanoate (AcOH). The heat mixing (HE) profile was recorded at (343.15 ± 0.1) K and fitted a 5-parameter Redlich-Kister (RK) polynomial. RK fit parameters subsequently used to quantify partial molar heats mixing, xiHiE, each component i. ITC-b...

The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands. We have recently determined the structure of mammalian TSPO/PBR in complex with the diagnostic ligand PK11195 [1-(2-chl...