نتایج جستجو برای: 203 ق

تعداد نتایج: 11911  

Journal: :Singapore Medical Journal 2020

Journal: :CALÍOPE: Presença Clássica 2017

Journal: :Circulation 2005
Hisashi Shimizu Masafumi Takahashi Takashi Kaneko Takashi Murakami Yoji Hakamata Shinji Kudou Tetsuya Kishi Kazunori Fukuchi Satoru Iwanami Kazuhiko Kuriyama Tokutaro Yasue Shin Enosawa Koshi Matsumoto Izumi Takeyoshi Yasuo Morishita Eiji Kobayashi

BACKGROUND A novel immunomodulator, KRP-203, the molecular structure of which has some similarity to FTY720, has been developed for use in organ transplantation. The present study was designed to investigate the potency and safety of KRP-203 on allograft survival against both acute and chronic rejection in rat skin and heart transplantation. METHODS AND RESULTS KRP-203 significantly prolonged...

2016
Mariko Obayashi Maki Yoshida Takaaki Tsunematsu Ikuko Ogawa Tomonori Sasahira Hiroki Kuniyasu Issei Imoto Yoshimitsu Abiko Dan Xu Saori Fukunaga Hidetoshi Tahara Yasusei Kudo Toshitaka Nagao Takashi Takata

Head and neck squamous cell carcinoma (HNSCC) has a high capacity for invasion. To identify microRNAs (miRNAs) that regulate HNSCC invasion, we compared miRNA expression profiles between a parent HNSCC cell line and a highly invasive clone. The miR-200 family and miR-203 were downregulated in the clone. Here we focused on the role of miR-203 in invasion and epithelial-mesenchymal transition (EM...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Shan Zhao De-Sheng Yao Jun-Ying Chen Nan Ding

MicroRNAs (miRNAs) are small, non-coding RNAs that are critical regulators of various diseases. MicroRNA- 20a (miR-20a) and microRNA-203 (miR-203) have previously shown significant alteration in a range of cancers. In this study, the expression levels of miR-20a and miR-203 in 100 cervical cancer tissues were detected by qRT-PCR and compared to patient matched-nontumor cervical tissues. Correla...

2017
Yuki Takano Takaaki Masuda Hisae Iinuma Rui Yamaguchi Kuniaki Sato Taro Tobo Hidenari Hirata Yosuke Kuroda Sho Nambara Naoki Hayashi Tomohiro Iguchi Shuhei Ito Hidetoshi Eguchi Takahiro Ochiya Katsuhiko Yanaga Satoru Miyano Koshi Mimori

A primary tumor can create a premetastatic niche in distant organs to facilitate the development of metastasis. The mechanism by which tumor cells communicate with host cells to develop premetastatic niches is unclear. We focused on the role of microRNA (miR) signaling in promoting metastasis. Here, we identified miR-203 as a signaling molecule between tumors and monocytes in metastatic colorec...

2016

هديكچ فده و هقباس : راتسرپ هفرح ي م رد سرتسارپ لغاشم ردص رد ي ب لغاشم نا تشاده ي نامرد و ي لـماوع و دراد رارـق سرتسا از ي لغش ي ددعتم ي ناور تملاس ي لغاش ي ا ن ي م رارق رطخ ضرعم رد ار هفرح ن ي دهد . فدـه اـب رـضاح شهوژپ سررب ي ت أ ث ي نت لماوع ر ي گد ي ناور تملاس رب از ي نانمس رهش ناراتسرپ دش ارجا . شور و داوم اه : رامآ هعماج ي زا دوب ترابع لك ي ر ناراتسرپ ه مس ي ب ي ناتسرام اه ي رهش هك ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده ادبیات و علوم انسانی 1390

دوران امامت امام رضا (ع) (203-183 هـ ق) را می توان دورانی کم نظیر از لحاظ اعتقادی، فرهنگی، و سیاسی محسوب نمود. افزایش تحرکات علویان در واپسین سال های امامت آن حضرت از مشخصه های این دوره می باشد؛ ویژگی های جنبش های علویان در این زمان، از جهات متعددی مانند: تعداد ،گستره ی جغرافیایی، خاندان های علوی شرکت کننده در آن و به تسلط درآوردن مناطق حساس خلافت عباسی بر اهمیت آن نهضت ها افزوده است و همین ویژ...

2016
Lin Xu Bin Shen Tingting Chen Pin Dong

The development of laryngeal squamous cell carcinoma (LSCC) is a multistep process involving multiple factors. MicroRNAs, a group of important negative regulators of gene expression, have also been confirmed to be involved in the LSCC pathogenesis. In the present study, we compared the expression of nine selected microRNAs in the LSCC tissues and adjacent nontumor tissues. We found that the exp...

Journal: :Cancer prevention research 2011
Sharanjot Saini Sumit Arora Shahana Majid Varahram Shahryari Yi Chen Guoren Deng Soichiro Yamamura Koji Ueno Rajvir Dahiya

Bladder cancer is often associated with recurrence and progression to invasive metastatic disease that have palliative therapeutic options. The use of traditional chemotherapeutic agents for bladder cancer management often suffers from toxicity and resistance concerns. This emphasizes the need for development of safer, natural, nontoxic compounds as chemotherapeutic/chemopreventive agents. Curc...

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