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MicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumour suppressors. We determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoural tissues and identified 42 differentially expressed miRNAs. We chose miR-215, miR-375, miR-378,...
BACKGROUND Greater time spent sedentary is linked with increased risk of breast, colorectal, ovarian, endometrial, and prostate cancers. Given steadily increasing rates of mobile phone ownership, mobile phone interventions may have the potential to broadly influence sedentary behavior across settings. OBJECTIVE The purpose of this study was to examine the short-term impact of a mobile phone i...
A computer-designed hydropathically complementary peptide to human interleukin 1 beta (IL1 beta) precursor sequence 204-215 recognized the 204-215 peptide as well the entire IL1 beta protein with binding affinities in the micromolar range. Interaction between the complementary pair was characterized by analytical high-performance liquid affinity chromatography on columns derivatized with the co...
The clinical prognosis of malignant gliomas is poor and PCDH9 down-regulation is strongly associated with its poor prognosis. But the mechanism of PCDH9 down-regulation is unknown. Abnormal miRNAs profiles regulate tumor phenotypes through inhibiting their target genes and miRNAs could inhibit target genes more efficiently by binding to both the promoter and 3'UTR of target genes. In this study...
Address correspondence and reprint requests to: Dr. Wen-Chao Song Institute for Translational Medicine and Therapeutics and Department of Pharmacology University of Pennsylvania School of Medicine, Rm 1254 BRBII/III, 421 Curie Blvd Philadelphia, PA 19104, Tel: 215-573-6641, Fax: 215-746-8941 [email protected] Blood First Edition Paper, prepublished online June 4, 2008; DOI 10.1182/bloo...
_________________________________________________________________________________________________ *Correspondence: Ralph Dornburg, The Dorrance H. Hamilton Laboratories, and Center for Human Virology, Division of Infectious Diseases, Jefferson Medical College. Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Room 329, Philadelphia, PA 19107. phone: 215-503-3117; fax: 215-...
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