MicroRNAs (miRNAs) have recently emerged as regulators of metastasis. We provide insight into the behavior of miR-221 in colorectal cancer (CRC) metastasis by showing that miR-221 is significantly upregulated in metastatic CRC cell lines and tissues. miR-221 overexpression enhances, whereas miR-221 depletion reduces CRC cell migration and invasion in vitro and metastasis in vivo. We identify RE...

OBJECTIVE To examine the patient characteristics linked with reduced adherence to inhaled corticosteroids (ICS) use. METHODS A prospective study of adult asthmatic patients who were prescribed with ICS and are under regular follow-up at the pulmonary outpatient clinics between June 1st, and December 31st, 2001, at King Fahad National Guard Hospital in Riyadh. All patients underwent structured...

The overexpression of microRNA-221 (miR-221) is reported in several human cancers including hepatocellular carcinoma, and its targeting by tailored treatments has been proposed. The evidence supporting the role ofmiR-221 in cancer is growing and has been mainly focused on the discovery of miR-221 targets as well as on its possible therapeutic exploitations. However, the mechanism sustaining miR...

Elhai et al.’s [1] study evaluates the frequency of radiological cervical spine involvement in young adults with polyarticular JIA (pJIA) compared with RA patients. The authors show that about two-thirds of patients in both groups had radiographic abnormalities in the cervical spine, including anterior atlantoaxial subluxation, erosion of the odontoid process, C1 C2 arthritis and apophyseal joi...

Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) are involved in cancer initiation and progression. Previous studies have indicated that miR-221 is one of the most consistently overexpressed miRNAs in multiple types of cancer. However, the role of miR-221 in osteosarcoma carcinogenesis and progression is not yet fully understood. Thus, the aim of the present study was to exa...

In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular oxidative stress induced by UVA irradiation in skin fibroblasts. We found that porphyra-334 significantly reduced the secretion and expression of ...

2010.6 The National Institute on Alcoholism and Alcohol Abuse (NIAAA) formed a special task force to make recommendations to address the problem.7 Binge drinking has even received global attention from the World Health Organization, which convened a conference to address the topic.8 Several prominent organizations and key leaders have accepted this call to action. Mothers Against Drunk Driving ...

Bladder cancer is one of the most common urological malignancies. Ninety percent of the bladder tumors are transitional cell carcinomas. The most important molecular mechanism in the development of carcinogenesis is the Deletions or inactivation of the cancer suppressor genes. Several suppressor gene loci have been closely associated with bladder cancer. These include p53 on chromosome 17p, ret...