Interleukin-23 (IL-23) and CD4(+) T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression. Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 production from dermal γδ T cells was independent of ...

Abstract— In screening the venoms of various snake species, we found that venom Madagascar cat-eyed Madagascarophis colubrinus competes with α-bungarotoxin for binding to nicotinic acetylcholine receptor from Torpedo californica . Using liquid chromatography, a peptide inhibits α‑bungartoxin this was isolated and named macoluxin. The amino acid sequence 23-amino determined by automatic Edman de...

Psoriasis is a chronic, immune-mediated disease affecting more than 100 million people worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. The manner in which genetic and environmental factors interact to contribute to the molecular disease mechanisms has remained elusive...

George Palade's pioneering work in the 1960s had established the secretory pathway and its connection to the biogenesis of organelles as a major theme in eukary-otic cell biology (Palade, 1975). His disciples, including David Sabatini and Gunter Blobel, extended Palade's morphological approaches to the next level of analysis, involving subcellular fractionation and biochemical re-constitution t...

The data herein is related to the research article entitled "Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex" [1] where we demonstrated that the chicken interleukin (IL)-23α, IL-12p40, and IL-23 complex regulates Th1, Th17, and Treg cytokine production through heterodimer receptors as well as a homodimer receptor cons...

The role of angiogenic molecules, like vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in tumor angiogenesis was well confirmed. Photodynamic therapy (PDT) action is, to very high degree, based on tumor vasculature damage. Therefore, it seemed to be important to evaluate growth factor receptors after PDT. The extent of receptor expression was studied by immuno-histo...