A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...

In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice. These studies showed that unlike “classical” PrP produced in vivo, the amyloid fibrils generated in vitro were more proteinase-K sensitive. Here we demonstrate that the amyloid form contains a proteinase K-resistant core...

BACKGROUND Malaria is one of the most devastating protozoal diseases in under developing countries like Pakistan where health facilities are scarce. It is the second most frequently reported disease with 4.5 million suspected cases in Pakistan. The current study was designed to determine the incidence of pediatric malaria in Quetta, Balochistan. METHODS The study was conducted at Children Hos...

Peroxinectin, a cell-adhesive peroxidase (homologous to human myeloperoxidase), from the crayfish Pacifastacus leniusculus, was shown by immuno-fluorescence to bind to the surface of crayfish blood cells (haemocytes). In order to identify a cell surface receptor for peroxinectin, labelled peroxinectin was incubated with a blot of haemocyte membrane proteins. It was found to specifically bind tw...

The induction of yeast Saccharomyces cerevisiae gene PHO5 expression is mediated by transcriptional factors PHO2 and PHO4. PHO4 protein has been reported to be phosphorylated and inactivated by a cyclin-CDK (cyclin-dependent kinase) complex, PHO80-PHO85. We report here that PHO2 can also be phosphorylated. A Ser-230 to Ala mutation in the consensus sequence (SPIK) recognized by cdc2/CDC28-relat...

A monolithically integrated tunable laser and quantum-well phase modulator is demonstrated. Phase efficiency under forward bias is improved >20dB at low frequencies compared with reverse bias. Bandwidths >30 GHz are demonstrated in frequency modulation measurements. 2006 Optical Society of America OCIS codes: (230 4110) Modulators; (230 5590) Quantum Well Devices This research was supported by...

Corresponding author: Hyungtae Kim, M.D., Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, University of Seonam College of Medicine, 365, Seowon-ro, Wansan-gu, Jeonju 560-750, Korea. Tel: 82-63-230-1593, Fax: 82-63-230-8128, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licen...

In the paper protection function setting calculations for elements of transmission system are shown. Analyzed consists 500 kV and 230 voltage levels. The shown several functions reactors, 500/230 kV/kV autotransformers line. Network modeling analysis have been performed using DIgSILENT PowerFactory.

BACKGROUND Ethanol production from non-crop materials, such as Jerusalem artichokes, would make a great contribution to the energy industry. The non-conventional yeast, Kluyveromyces marxianus, is able to carry out ethanol fermentation of sugar molecules obtained from inulin-containing materials by consolidated bioprocessing. Lower inulin concentrations and micro-aeration can lead to a relative...

A 230 kDa polypeptide component of the hemidesmosome, an epithelial-cell-connective-tissue attachment device, is thought to be involved in cytoskeleton-cell-surface anchorage. This 230 kDa polypeptide is recognized by bullous pemphigoid auto-antibodies and for this reason is generally termed the bullous pemphigoid antigen (BPA). We have identified two distinct mRNA products of the single BPA ge...