BACKGROUND KDOQI guideline suggests that nutritional vitamin D should be supplemented in chronic kidney disease (CKD) patients who have vitamin D insufficiency/deficiency. However, there are scarce data regarding the additional benefit of active vitamin D supplement in CKD patients who were receiving nutritional vitamin D supplement. This study was conducted to explore the effect of adding acti...

Multi-Site Phosphorylation of Oxysterol Binding Protein (OSBP) Regulates Sterol Binding and Activation of Sphingomyelin Synthesis Asako Goto, Xinwei Liu, Carolyn-Ann Robinson and Neale D. Ridgway The Atlantic Research Centre, Depts. of Pediatrics, and Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2 *Running Head: Phosphorylation regulation of OSBP Ad...

BACKGROUND Improving prediction of treatment outcomes in chronic hepatitis C (CHC) genotype 4 (G4) is necessary to increase sustained viral response (SVR) rates. Vitamin D related and interferon stimulated genes are good candidates as they are recently crosstalk altering interferon response. Thus single nucleotide polymorphisms (SNPs) within some of these genes and multiple stepwise regression ...

Management of patients with mild primary hyperparathyroidism (PHPT) has been widely discussed because most patients today do not have specific symptoms. While surgery is always an option, the recommendations for treatment have shifted, which mostly reflects changes in clinical practice. In this study, we aimed to evaluate evidence for the current recommendations concerning operation vs observat...

INTRODUCTION Even though renal function decline is considered relentless in chronic kidney disease (CKD), improvement has been shown in patients with hypertensive nephropathy. Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve. METHODS We identified 406 patients in the NephroTest cohort with glomerular filtration rates (mG...

Background: The impact of diabetic foot infections is enormous in India. Studies on vitamin D levels in diabetes mellitus foot infections are scarce. The primary objective of the present study was to compare the serum vitamin D level between diabetics with foot infections and those without foot infections and the secondary objective was to assess the association between the vitamin D level and ...

Background: Vitamin D regulates the innate and adaptive immune system responses low vitamin levels have been associated with increased risk of respiratory tract infections (1). deficiency has recently reported to interfere prognosis COVID-19 (2,3). Objectives: The aim this study was correlate 25OH-vitamin serum lung involvement disease severity, in a cohort elderly patients hospitalized for SAR...

Abstract Background and Aims INitiativeS on advancing Patients’ outcomes In REnal disease (INSPIRE) is an academia industry collaboration set forth to identify critical investigations needed advance the practice of medicine in nephrology. At inaugural INSPIRE meeting, group came a consensus that major bleeding events represent potentially preventable complications occur more frequently people w...