BACKGROUND The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...

Akt is classically described as a prosurvival serine/threonine kinase activated in response to trophic factors. After activation by phosphoinositide 3-kinase (PI3-kinase), it can translocate to the nucleus where it promotes specific genetic programs by catalyzing phosphorylation of transcription factors. We report here that both dopamine (DA) D1 (SKF38393) and D2 (quinpirole) agonist treatments...

Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) and tumour necrosis factor (TNF) (-308 G/A, rs1800629 and -238 G/A, rs3...

OBJECTIVES The tumor necrosis factor-alpha (TNF-α) gene may play an important role in coronary heart disease (CHD) and myocardial infarction (MI) risk. Recently, controversial results regarding the association of the G-308 A (rs1800629)polymorphism of the TNF-α gene with CHD/MI have been reported. We herein examine a possible association between the G-308 A (rs1800629)polymorphism of the TNF-α ...

BACKGROUND DATA Narrow band ultraviolet B (UVB) is an effective and safe option for the treatment of vitiligo. However, a complete and long-lasting repigmention of vitiligo patches is difficult to achieve. Combined treatments with novel sources of phototherapy and topical agents represent possible new strategies. OBJECTIVE The purpose of this study was to compare the efficacy of combined tacr...

BACKGROUND AND OBJECTIVE The association between TNF-α -308 G/A polymorphism and COPD remains controversial due to insufficiently strict study designs and small group sizes among different studies. In the present study, a meta-analysis update which followed a stricter procedure was performed to obtain a clearer understanding of this association. METHODS A comprehensive database search was con...

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OBJECTIVE To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser. DESIGN Controlled study with a before-after design. SETTING A university-based clinical research center. PATIENTS Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months. INTERVENTIONS Selected psoriatic plaques were treated with the 3...

Introduction: Gastric cancer (GC) is one of the leading causes cancer-related decimations worldwide. The gastric infection at both stomach and duodenum with Helicobacter pylori inflammation by tumor necrosis factor-alpha (TNF-?). aim study was to associate evaluate three TNF-? gene polymorphisms positions ?308 G/A, ?238 ?857 C/T risk GC. Methods: A total 156 individuals (consecutively diagnosed...