BACKGROUND Abacavir is one of the recommended nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infections among children and adolescents. However, there are concerns that the antiviral efficacy of abacavir might be low when compared to other NRTIs especially among children. There are also concerns that abacavir use may lead to serious adverse events such as hypersens...

The construction of vascular systems during organ development has provided a model for studying pattern formation as well as tissue differentiation in plants. One can recognize a rich variety of patterns in vascular systems among different species and organs. Despite such diversity in the apparent vascular patterns, it has been thought that a common basic mechanism underlies spatial regulation ...

s and titles from the Cranfield collection (with 225 queries and 1400 documents), comprised the major test collection for this study. The Medlars collection (30 queries and 1033 documents), and the CACM collection (64 queries and 3204 documents) were used to provide information about the variation of stemming performance across different subject areas and test collections. In addition to the st...

BACKGROUND Tissue hypoperfusion and inflammation in sepsis can lead to organ failure including kidney and liver. In sepsis, mortality of acute kidney injury increases by more than 50%. Which type of volume replacement should be used is still an ongoing debate. We investigated the effect of different volume strategies on inflammatory mediators in kidney and liver in an early sepsis model. MATE...

Both the clinical course and molecular alterations of sickle cell anemia (Hb SS) are highly distinct. Possible modulators of phenotypical variability have been documented, including alpha-thalassemia and beta S-globin gene cluster haplotypes. (1) The possible benefits of alpha thalassemia co-inheritance also affect hematological parameters. (2) The Hb S intra-cellular concentration seems to pre...

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract This document describes the use ...

Foxm1, a mammalian Forkhead Box M1 protein, is known as a typical proliferation-associated transcription factor. Here, we find that Foxm1 was essential for maintenance of hematopoietic stem cell (HSC) quiescence and self-renewal capacity in vivo in mice. Reducing expression of FOXM1 also decreased quiescence in human CD34+ HSCs and progenitor cells and its downregulation was associated with a s...

BACKGROUND Nepal Pediatric Ocular Diseases Study is a three year longitudinal population based study. Here we present the baseline survey report which aims to investigate various risk factors associated with childhood ocular morbidity and blindness in three ecological regions of Nepal. METHOD This baseline survey is a population based cross sectional study. The investigation was conducted in ...

IT was with some self-consciousness that I accepted an genetic (determinative) aspect to the regulation of the X-linked gene that coordinately controls Drosophila sexinvitation to reflect on my own work, a long Genetics article that appeared 20 years ago entitled, “Autoregulaual fate and X chromosome dosage compensation in response to X chromosome dose and for revealing a positive tory Function...