www.sciencemag.org (this information is current as of October 20, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/322/5900/449 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5900/449/DC1 can be foun...

The lacY gene of Escherichia coli, which encodes the lac permease, has been modified by oligonucleotide-directed, site-specific mutagenesis such that each of the four histidine residues in the molecule is replaced with an arginine residue. Replacement of histidine-35 and histidine-39 with arginine has no apparent effect on permease activity. In contrast, replacement of either histidine-205 or h...

ABSTRACT: The present study described the prevalence and factors associated with seropositivity for anti-Brucella spp. antibodies in working equids semiarid regionofnortheastern Brazil. Blood samples were collected from 322 (76 horses, 155 mules 91 donkeys). Rose Bengal plate test (RBPT) was used as a screening method. Samples that reactive RBPT tested confirmation using 2-mercaptoethanol (2-ME...

Ginger L. Milne, Huiyong Yin, and Jason D. Morrow Division of Clinical Pharmacology, Departments of Medicine and Pharmacology Vanderbilt University School of Medicine, 23 Avenue South at Pierce Avenue, Nashville, TN 37232-6602 Address correspondence to: Jason D. Morrow M.D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 23...

INTRODUCTION Body surface mapping (BSM) can be used to identify the site of earliest endocardial activation of ventricular tachycardias (VTs). The multielectrode QRS morphology during VT is determined by both the site of earliest activation and the subsequent spread of electrical activation through the ventricles. This study investigated the relationship between the site of earliest endocardial...

Vapor pressure: 1.33×10 Pa (108.2°C) Partition coefficient: Log Pow = 3.18 (observed value) Degradability: Hydrolyzability: No Report Biodegradability: Poorly biodegradable (BOD=0%, 14 days) Solubility: Water: 137 mg/l (25°C) (observed value) Organic solvents: Soluble in acetone and benzene. Amount of production/import:(1998): 322 t (Production 0 t, Import 322 t) Usage: Raw material for synthes...

MicroRNAs (miRNAs) have been implicated in a variety of physiological processes, however, the function of miRNAs in insulin secretion and type 2 diabetes is still unclear. Stxbp1 plays an essential role in exocytosis, and is crucial for insulin secretion. In this study, we focused on the molecular mechanism of Stxbp1 in insulin secretion by identifying its upstream regulators: miR-218 and miR-3...

Recent genome-wide association studies reveal that the FAM13A gene is associated with human lung function and a variety of lung diseases, including chronic obstructive pulmonary disease, asthma, lung cancer, and pulmonary fibrosis. The biological functions of Fam13a, however, have not been studied. In an effort to identify novel substrates of B56-containing PP2As, we found that B56-containing P...

www.sciencemag.org (this information is current as of December 4, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/322/5907/1559 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5907/1559/DC1 can be fo...

[This retracts the article on p. 322 in vol. 9.].